DEVELOPMENT OF TECHNOLOGY AND ANALYSIS OF HERBAL OINTMENT WITH OIL EXTRACT OF MELILOTUS OFFICINALIS

The herb of melilotus officinalis has a rich set of biologically active substances with a variety of pharmacological action. Meli- lotus officinalis is widely used in folk and official medicine only in the form of infusions and decoctions, and is also a part of various teas. This work is devoted to the study of the melilotus officinalis herb, oil extract and ointment obtained on its basis. In the course of experimental studies by pressing with pre extraction of soybean oil oil extract of melilot was obtained; the optimal composition was developed and the rational technology of semisolid dosage form - ointment based on it was proposed. A «cross - cutting» standardization in the series «medicinal plant raw materials - intermediate product-dosage form» was carried out. The data obtained as a result of the experiment indicate the feasibility of heat treatment in the preparation of oil extract of melilotus officinalis, increasing the content of the main active substances in the finished product. The content of carotenoids in the proposed ointment was 3,88 % with a relative error of ± 1,87 % (spectrophotometric method). It is proved that the ointment has sufficient osmotic activity, absorbing almost twice the amount of water with little noticeable change in consistency; satisfactory spreading ability; good bioadhesion.

донник лекарственный, масляный экстракт, мазь, каротиноиды, спектрофотометрия, Melilotus officinalis, oil extract, ointment, carotenoids, spectrophotometry