EFFECTIVENESS OF RETINAL VEIN «MASSAGE» IN CASE OF PHOTO-INDUCED THROMBOSIS UNDER EXPERIMENT

Abstract

On the model of photo-induced central retinal vein thrombosis (CRVO) and its branches thrombosis (BRVO), the efficacy of retinal veins «massage» in comparison with epiretinal thrombolysis was determined. The experiment was performed on 30 Chinchil-la rabbits (30 eyes), with simulation of retinal vein occlusion by introducing a photosensitizer and laser irradiation of retinal blood vessels. On the third day after the induction of CRVO and BRVO under general anesthesia 15 animals of the main group (15 eyes) underwent «massage» of the affected vessel with tipped scrapper 25G; 15 animals of the control group (15 eyes) epiretinally were injected 500 IU of gemaza. Before treatment, om 1st, 7th, 14th, 21th days after surgery ophthalmoscopy was performed. Before treatment, on 7th, 21st days after the intervention optical coherence tomography and fluorescein angiography were performed, and each time 5 animals were drown out with subsequent enucleation of eyeballs for light microscopy.It was found that «massage» of the affected retinal vein helps to restore blood flow in the vessel, as evidenced by the reductionof venous perfusion time by 1.3 times, and faster by 1.45 times resorption of central retinal departments edema, compared with epiretinal introduction of gemaza. These histological studies revealed no iatrogenic damage to blood vessels and retina during «massage « of the veins, indicating the safety of manipulation.