ROLE OF TUMOR-ASSOCIATED MACROPHAGES IN THE PATHOGENESIS OF VARIOUS CANCER SPECIES
Abstract
The stroma of the neoplasm plays an important role in the pathogenesis of malignant tumors. One of the main elements of the tumor stroma are tumor associated macrophages (TAMs), which can stimulate uncontrolled cell proliferation and vascular network growth, as well as inhibit antitumor immunity, which leads to tumor progression [1]. The malignant potential of TAMs is expressed in the secretion of growth factors, extracellular matrix compounds, and the induction of the synthesis of certain cytokines [8]. Quantitative accounting of TAMs is actively used as a prognostic marker, however, the study using various markers of M1 and M2 macrophages will more confidently determine the concept of therapy aimed at inhibiting the pro-oncogenic activity of TAMs [1]. The aim of the work is to study the latest markers of TAMs, which will be useful as both prognostic and diagnostic markers of tumors or will be applicable in the field of creating new targeted antitumor drugs [8].
About the Authors
E. R. Yakupova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
G. M. Tuguzbaeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
I. R. Kabirov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; Клиника ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
M. F. Urmantsev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; Клиника ФГБОУ ВО БГМУ Минздрава России
Russian Federation
Russian Federation
I. M. Nasibullin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
E. G. Usmanov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
O. A. Zabolotnyi
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Review
For citations:
Yakupova E.R., Tuguzbaeva G.M., Kabirov I.R., Urmantsev M.F., Nasibullin I.M., Usmanov E.G., Zabolotnyi O.A. ROLE OF TUMOR-ASSOCIATED MACROPHAGES IN THE PATHOGENESIS OF VARIOUS CANCER SPECIES. Bashkortostan Medical Journal. 2020;15(1):79-87. (In Russ.)
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