DIAGNOSTIC VALUE OF FETAL HEMOGLOBIN IN CASE OF IRON DEFICIENCY ANEMIA IN NEWBORNS BORN WITH IRON-DEFICIENCY ANEMIA

Abstract

The purpose of this study was to determine the amount of fetal hemoglobin in newborns with iron-deficiency anemia (IDA)born from mothers suffering from iron-deficiency anemia during pregnancy.Materials and methods: levels of hemoglobin and fetal hemoglobin were studied in 81 newborns with IDA born from mothers who were diagnosed with iron deficiency anemia during pregnancy.Results: The results of the study showed that in children with iron deficiency anemia who are in conditions of prolonged hypoxia during prenatal development, born from mothers with IDA, a decrease in hemoglobin concentration to - 116.3 ± 2.07 g / l (P<0.021) is observed, in contrast to children born from mothers without IDA (178.8 ± 0.49 g / l; P <0.021). At the same time, there was also a difference in the rate of fetal hemoglobin in newborns with iron deficiency anemia, who are under conditions of pro-longed hypoxia during the period of intrauterine development, born from mothers with IDA, than in children born from motherswithout IDA. In newborns and young children with IDA, born from mothers with IDA, due to impaired oxygen delivery through a morphologically and functionally altered placenta, fetal stress and hypoxia develop during fetal development.Conclusions: Long-term chronic hypoxia is characterized by persistent disorders of oxidative processes in tissues, followed by theprogression of dystrophic changes in various tissues and organs and the development of decompensation of the function of vital organs and systems. In children whose intrauterine development proceeded against the background of IDA in the mother, due to prolonged chronic hypoxia, the content of fetal hemoglobin was higher than in children whose intrauterine development was not burdened by IDA, which determines the significance of the indicator of fetal hemoglobin in iron deficiency anemia in young children.