SUCCESSFUL TREATMENT OF FUNGAL KERATITIS AFTER PENETRATING KERATOPLASTY
Abstract
Infectious keratitis is the most common complication of penetrating keratoplasty. The article analyzes a case of fungal keratitis after penetrating keratoplasty. Keratoplasty was performed for bullous keratopathy developed after open globe injury in a35-years old man. The fungal keratitis occurred two weeks later on the edge of the donor flap. The instillation of steroids and antibiotics was discontinued, specific treatment included fluconazole and amphotericin B, keratitis repeatedly recurred, infiltrates werescraped. Topical and systemic voriconazole during 3 weeks resulted in stable corneal epithelialization and corneal transparency res-toration. During 3 years of follow-up keratitis did not recur, visual acuity achieved to 1.0.
About the Authors
S. N. Svetozarskiy
ФБУЗ «Приволжский окружной медицинский центр» ФМБА России
Russian Federation
Russian Federation
A. N. Andreev
ФБУЗ «Приволжский окружной медицинский центр» ФМБА России
Russian Federation
Russian Federation
S. V. Scherbakova
ФБУЗ «Приволжский окружной медицинский центр» ФМБА России
Russian Federation
Russian Federation
I. G. Smetankin
ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России
Russian Federation
Russian Federation
References
1. A comparative, retrospective, observational study of the clinical and microbiological profiles of post-penetrating keratoplasty keratitis / I. Lin [et al.] // Sci Rep. - 2016. - Vol. 6, № 1. - P. 32751
2. Ansari, Z. Current Thoughts in Fungal Keratitis: Diagnosis and Treatment / Z. Ansari, D. Miller, A. Galor // Current Fungal Infection Reports. -2013. - Vol. 7, №3. - P. 209-218
3. FlorCruz, N. Medical interventions for fungal keratitis / N. FlorCruz, J. Evans // Cochrane Database Syst. Rev. - 2015. - Vol. 9. - P. CD004241
4. Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center / J. Ho [et al.] // J. Ophthalmic Inflamm Infect. - 2016. - Vol. 6, № 1. - P. 5
5. Poltanova, T. Recurrence of fungal keratitis in corneal transplant / T. Poltanova, N. Belousova // Kazan medical journal. - 2018. - Vol. 99, №1. P. 148-150
6. Randomised trial of 0.2% chlorhexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh / M. Rahmanet al. // British Journal of Ophthalmology. - 1998. - Vol. 82, №8. - P. 919-925
7. Review of clinical and basic approaches of fungal keratitis / J. Wu [et al.] // Int. J. Ophthalmol. - 2016. - Vol. 9, № 11. - P. 1676-1683
8. Risk factors, clinical presentations, prevention, and treatment of corneal graft rejection / S. Trufanov et al. // Vestnik oftal'mologii. - 2016. - Vol. 132, №6. - P. 108-116
9. Srinivasan, M. Fungal keratitis / M. Srinivasan // Current Opinion in Ophthalmology. - 2004. - Vol. 15, № 4. - P. 321-327
10. Wang, T. Therapeutic dilemma in fungal keratitis: administration of steroids for immune rejection early after keratoplasty / T. Wang, S. Li, H. Gao, W. Shi // Graefe's Archive for Clinical and Experimental Ophthalmology. - 2016. - Vol. 254, №8. - P. 1585-1589
Review
For citations:
Svetozarskiy S.N., Andreev A.N., Scherbakova S.V., Smetankin I.G. SUCCESSFUL TREATMENT OF FUNGAL KERATITIS AFTER PENETRATING KERATOPLASTY. Bashkortostan Medical Journal. 2020;15(4):17-20. (In Russ.)
Views:
70
Email this article 
