ADVERSE EFFECTS OF ANTIRETROVIRAL THERAPY DEPENDING ON THE TREATMENT SCHEME OF PATIENTS WITH HIV INFECTION

Abstract

Objective. To determine the side effects of the antiretroviral therapy, depending on the treatment scheme of patients with HIVinfection.Material and methods.173 patients were under observation, registered at the AIDS Centers in the cities of Tashkent and Ufa and at the Republican Clinical Perinatal Center in the city of Ufa. Of these, 82 (47.4%) were male patients and 91 (52.6%) were female. The number of patients from 8 to 14 years old was 69 (39.9%) (39 boys and 30 girls); from 15 to 17 years old - 84 (48.5%) (43 boys and 41 girls), respectively; and from 18 to 30 years old - 20 pregnant women (11.6%). Side-effect studies have been conducted with six different antiretroviral therapy regimens in HIV-infected patients.Results. Gastroenterological, neurological, allergic, hematological side effects were revealed with six different ARVT regimens. The study found that the greatest number of gastrointestinal side effects was found with the use of ABC + 3TC + LPV / r (87%). Psycho-neurological side effects were most pronounced with AZT + 3TC + EFV (52.8%), allergic side effects - when using ABC +3TC + NVP (27.3%). Side effects in the form of anemia were most pronounced with AZT + 3TC + NVP (25%). Conclusion. The study showed that it is necessary to approach each patient in a personalized manner at the time of prescribing antiretroviral therapy, taking into account the clinical condition, comorbidities, comorbid conditions of the patient and possible side effects of the applied ARVT regimen.