COMPARATIVE ANALYSIS OF THE POLYMORPHIC MARKER RS1131341 OF THE NQO1 GENE IN POPULATIONS FROM DIFFERENT ECOLOGICAL REGIONS

In order to study the role of the genes of the enzymes of free radical and toxic compounds metabolism in the development of the adaptive background, the susceptibility to extraneous agents and the resistance to infectious diseases, we carried out a comparative analysis of the allelic distribution in the NQO1 gene of rs1131341polymorphic marker in populations from different ecological regions. We studied 2713 people belonging to ethnic groups of Russians (n=490), Bashkirs (n=492), Tatars (n=1529) and Abkhazians (n=202). Allelic variants of the NQO1 gene were identified by PCR-RFLP. Population heterogeneity was analyzed using the Arlequn program (V. 3.0). Among the four ethnic groups, the highest level of heterogeneity was found between groups of people living in different environmental conditions - Abkhazians and residents of the Republic of Bashkortostan (P<0.05). Abkhazians also differ significantly from individuals from other world populations (P<0.05). The ethnic groups of Tatars, Bashkirs, and residents of East Asia showed a similar character of genotypes frequencies distribution (P=1).

ecological adaptation, ethnic group, free radical, xenobiotic metabolism, NQO1 gene, genetic polymorphism

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