COMPARATIVE ANALYSIS OF ANTIEPILEPTIC DRUGS EFFECT ON THE CENTRAL NERVOUS SYSTEM
Abstract
Aim: to evaluate the effect of antiepileptics on the central nervous system (CNS) in children and adults.Material and methods. The treatment of 428 patients with epilepsy, 301 (70.3%) under 18 years old, 127 (29.7%) over 18 years old, 195 - males (45.6%), 233 (54.4%) - females was analyzed.Results. 359 adverse drug reactions (ADRs) were recorded in 223 patients (52.1%). ADRs were registered in 86/223 (38.6%)men and in 37/223 (61.4%) women, and 100/359 (28%) ADRs concerned the effect on CNS. The most significant among them were drowsiness, dizziness, cognitive-behavioral impairment, diplopia. ADR associated with CNS damage was most often detected with carbamazepine and oxcarbazepine (45 and 44%), lamotrigine and topiramate (33 and 28% of cases, respectively). Valproate (19%)and levetiracetam (18%) also effected on the CNS.Conclusions. In 1/3 of cases, antiepileptic ADRs are associated with the CNS effect, often due to the use of carbamazepine, the least - with levetiracetam.
About the Authors
R. M. Shaimardanova
ГАУЗ «Детская городская больница №8 им. А.Ю. Ратнера»
Russian Federation
Russian Federation
R. G. Gamirova
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГАОУ ВО «Казанский (Приволжский) федеральный университет»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ГАУЗ «Детская городская больница №8 им. А.Ю. Ратнера»
Russian Federation
Russian Federation
E. A. Gorobets
ФГАОУ ВО «Казанский (Приволжский) федеральный университет»
Russian Federation
Russian Federation
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Review
For citations:
Shaimardanova R.M., Gamirova R.G., Gorobets E.A. COMPARATIVE ANALYSIS OF ANTIEPILEPTIC DRUGS EFFECT ON THE CENTRAL NERVOUS SYSTEM. Bashkortostan Medical Journal. 2020;15(6):16-21. (In Russ.)
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