STUDY OF THE RANGE OF EFFECTIVE DOSES OF A NEW 3-SUBSTITUTED THIETANE-1,1-DIOXIDE DERIVATIVE

Abstract

Aim: to study the range of effective doses of a new 3-substituted thietane-1,1-dioxide derivative (laboratory code N-199/1), which has antidepressant activity. Materias and methods: in the experiment, the N-199/1 acute toxicity (LD50) was determined according to the method of J. Litchfield and F. Wilcoxon modified by V.B. Prozorovskii when administered once intraperitoneally to male mice, which amounted to 488.85 mg/kg (IV class of hazard - «low-toxic substances», classification of K.K. Sidorov). The compound was administered once per day intraperitoneally for 14 days to outbred male mice at doses of 0.9, 2, 4.5, 10.1, 22.8, and 51.3 mg/kg, which are 1/546, 1/243, 1/108, 1/48,1/29 and 1/9 of the LD50 respectively.Results and conclusions: in the forced swimming test modified by E.V. Shchetinin N-199/1 reduced the depression index by 17-27% in relation to the control group at doses of 0.9 - 22.8 mg/kg, and the duration of immobilization by 37%, 56% and 32% at doses of 2, 10.1 and 22.8 mg/kg respectively. Thus, with repeated intraperitoneal administration to male mice, N-199/1 in a wide range of doses (0.9-22.8 mg / kg) showed antidepressant-like properties.