SYNTHESIS OF NEW HYDRAZONES BASED ON 6-METHYL-1- (2-OXOPROPYL)-3- (THIETAN-3-IL) PYRIMIDIN-2,4(1H,3H)-DIONE HAVING BIOLOGICAL ACTIVITY

Abstract

Medicines, the molecule of which contains a hydrazone fragment, are widely used as antibacterial and antioxidant agents. Pyrimidine derivatives show high activity in the treatment of Alzheimer's disease, have antioxidant, antitumor, antiviral activity. Therefore, the prospects for the synthesis of previously undescribed hydrazones 6-methyl-1- (2-oxopropyl) -3- (thietan-3-yl) pyrimidin-2,4 (1H, 3H) -dione containing a pyrimidine ring and a hydrazone residue as the pharmacophore fragment, is of interest for obtaining new series of potential biologically active substances.Purpose: In order to obtain new methyluracil derivatives, we studied the alkylation of 6-methyl-3- (thietan-3-yl) pyrimidine-2,4(1H, 3H) -dione with chloroacetone and the interaction of the resulting 2-oxopropyl derivative with hydrazine derivatives.Material and methods: The structure of the newly synthesized substances was investigated by NMR spectroscopy. The prediction of biological activity and toxicity was carried out using the online resources PASS and GUSAR. Statistical processing of the results was carried out using the method of correlation analysis using the universal software package STATISTICA 8.0Results and conclusions: As a result of the work, a new series of compounds with potential biological activity was obtained. Some structure-activity relationships have been identified. Based on the data obtained, promising areas of research have been formed that directly cover the study of predicted types of biological activity.