СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ КЛИНИЧЕСКОГО ПРИМЕНЕНИЯ СТРОМАЛЬНО-ВАСКУЛЯРНОЙ ФРАКЦИИ ЖИРОВОЙ ТКАНИ

Основанная на выделении из жировой ткани стромально-васкулярная фракция (СВФ) представляет собой гетерогенную клеточную популяцию эндотелиоцитов, эритроцитов, фибробластов, клеток гладкой мускулатуры, перицитов, макрофагов и мезенхимальных стволовых клеток, которые имеют пластически-адгезивный характер. Мезенхимальные стволовые клетки обеспечивают противовоспалительное, иммуномодулирующее и антиапоптотическое действие, а также стимулируют ангиогенез, рост и дифференцировку тканей в месте повреждения. Поэтому СВФ имеет огромный потенциал для терапевтического применения при заболеваниях, сопровождающихся локальным повреждением мягких тканей и развитием воспалительного процесса. Несмотря на то, что использование СВФ полезно для лечения многих заболеваний, таких как дегенеративные заболевания опорно-двигательного аппарата или сердечно-сосудистые заболевания, в настоящее время они широко не используются в клинической практике. Несмотря на обширные исследования, точные механизмы воздействия СВФ на регенеративные процессы все еще неясны, что, несомненно, препятствует применению СВФ в терапевтических целях. Представленная работа освещает результаты исследований, опубликованных в современной литературе и посвященных механизмам действия СВФ, а также потенциалу ее использования при различных заболеваниях человека.

стромально-васкулярная фракция, патология, механизм, клинические исследования, терапия, склероз, микроциркуляция

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