CLINICAL AND MORPHOLOGICAL FEATURES OF UTERINE FIBROID IN PATIENTS OF REPRODUCTIVE AGE

Abstract

Aim: to establish the clinical and morphological features of uterine fibroids, depending on the level of expression α-SMA, CD34, Ki-67 receptors.Material and methods. We carried out a retrospective analysis of the case histories of patients diagnosed with uterine fibroidsafter surgical treatment in the gynecological department of the clinic of obstetrics and gynecology of the Medical Academy named after S.M. Kirov for the period of 2017-2020.In total, the study included data from the case histories of 110 patients who underwent laparoscopic myomectomy. The size ofthe removed tumor exceeded 8 cm. According to the results of immunohistochemical studies, the patients were divided into 2 groups: the expression of α-SMA, CD34, Ki-67 less than 1% - 1 group (n = 58), the expression of α-SMA, CD-34, Ki-67 from 1% -5% - group 2 (n = 52).Statistical analysis was carried out using Microsoft Office Excel programs and R - Studio software environment.Results. The increased expression level of α-SMA, CD34, Ki-67 (1-5%) is reliably associated with multiple uterine myoma (p = 0.0003), rapid growth of the myoma node (p = 0.004). Also, a significant correlation was found between the volume of intraoperative blood loss and the degree of expression of proliferation receptors (p = 0.0007).Conclusion. Increased expression of proliferation factors can be considered as a criterion for predicting recurrence of fibroids in patients of reproductive age, which determines the need for dynamic monitoring and preventive anti-relapse therapy.