CLINICAL MANIFESTATIONS AND COMORBIDITY IN PATIENTS WITH AGE-RELATED, POSTTRAUMATIC, METABOLICAND MIXED GENESIS OF GONARTHROSIS

Abstract

Objective was to identify and analyze clinical features and prevalence of comorbid pathology in patients with agerelated, posttraumatic, metabolic and mixed genesis of gonarthrosis.Material and methods. The study was conducted on 120 patients with III-IV radiological stages of gonarthrosis, divided into 4groups of 30 people, depending on osteoarthritis (OA) phenotype: agerelated, posttraumatic, metabolic and mixed. All patients underwent clinical examination of basic and comorbid diseases with collection of complaints, anamnesis, physical examination, verification of comorbid pathology, knee joints X-ray and statistical processing of data obtained.Results. Agerelated OA was characterized by the latest onset, the highest age of patients, rare synovitis, high prevalence of coronary heart disease, arterial hypertension, osteoporosis, hypothyroidism, and abdominal obesity without metabolic syndrome. Posttraumatic OA was characterized by the lowest prevalence of comorbid pathology, except for chronic cholecystitis. Metabolic phenotype was accompanied by frequent synovitis, IV OA stage, frequent cardiovascular, endocrine, metabolic and gastrointestinal comorbidities. Mixed OA was characterized by frequent comorbid metabolic and endocrine disorders and chronic gastritis.Conclusion. Revealed clinical and pathogenetic differences between phenotypes of gonarthrosis require individualized approachto treatment of different categories of patients with OA, taking into account comorbid pathology.