CHARACTERISTICS OF IGG CLASS ANTIBODY TO EPSTEIN-BARR VIRUS ANTIGENS IN VARIOUS PHENOTYPES OF CHRONIC RESPIRATORY PATHOLOGY
Abstract
The article is devoted to the study of the humoral immune response to Epstein-Barr virus (EBV) proteins in respiratory pathology.The aim of the study was to identify the features of the immune system response to EBV proteins in different clinical phenotypes of chronic respiratory pathology.Material and methods. 140 patients were examined using immunoblotting for semi-quantitative evaluation of IgG antibodies to virus-specific capsid, nuclear, and early EBV proteins.Results. In rhinosinusitis and bronchial asthma induced by nonsteroidal anti-inflammatory drugs (NSAIDs), the pattern of anti-bodies AVCAgp125+/VCAp19+/EBNA-1+/p22+/EA-D-prevailed. High-titer antibodies to VCAgp125 were found in all patients with rhinosinusitis and 62.5% with asthma. In atopic asthma, antibody profiles uncharacteristic of NSAID hypersensitivity were detected in 40.2% of cases.Conclusion. Bronchial asthma and rhinosinusitis associated with NSAID intolerance develop against the background of chronic EBV infection (IVEB) and have a similar spectrum of IgG antiviral antibodies. The type of immune response to EBV proteins in allergic and NSAID-induced variants of bronchial asthma is different.
About the Authors
N. A. Suzdaltseva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
T. V. Suzdaltseva
АО «Лечебно-диагностический центр иммунологии и аллергологии»
Russian Federation
Russian Federation
D. A. Valishin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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For citations:
Suzdaltseva N.A., Suzdaltseva T.V., Valishin D.A. CHARACTERISTICS OF IGG CLASS ANTIBODY TO EPSTEIN-BARR VIRUS ANTIGENS IN VARIOUS PHENOTYPES OF CHRONIC RESPIRATORY PATHOLOGY. Bashkortostan Medical Journal. 2021;16(1):37-41. (In Russ.)
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