STUDY OF ANTI-DEPRESSIVE ACTION MECHANISM OF A NEW DERIVATIVE OF 1- (THIETANYL-3) IMIDAZOLES IN TESTS OF NEUROPHARMACOLOGICAL INTERACTION

Depression is a widespread disease throughout the world. Currently existing methods of pharmacotherapy are effective only in30-40% of patients, which makes the search for new effective and safe drugs with antidepressant activity relevant [10]. In our earlier studies, we have found compounds from a number of 1- (thietanyl-3) imidazole derivatives exhibiting antidepressant activity [13]. Compound I (dipotassium salt of 2-bromo-1- (thietanyl-3) imidazole-4,5-dicarboxylic acid) has low toxicity and exhibits pronounced antidepressant properties, which characterizes this molecule as promising for further indepth study.Медицинский вестник Башкортостана. Том 16, № 1 (91), 202153Therefore , the aim of this work was to study the mechanism of action of compound I in tests of neuropharmacological interaction.Research methods. To assess the effect of 1- (thietanyl-3) imidazole derivative on dopaminergic and / or noradrenergic neurotransmission, tests of apomorphine hypothermia and haloperidol catalepsy were used. The ability of the studied compound to alter serotonergic neurotransmission was studied in the 5-hydroxytryptophan (5-OTP) hyperkinesis test, and in the L-DOPA test, the ability of compound I to inhibit the activity of monoamine oxidase was assessed.The results of the studies showed that when administered to non-inbred male mice, compound I (2 and 14 mg / kg once intraperitoneally) aggravated apomorphic hypothermia, reduced the severity of haloperidol catalepsy and 5-OTP-induced hyperkinesis and did not affect the effect of low doses of L-DOPA.Сonclusion. Thus, the antidepressant-like effect of compound I is possibly associated with the activation of dopaminergic and suppression of serotonergic neurotransmissions, but not with the effect on the activity of monoamine oxidase.

apomorphine hypothermia, haloperidol catalepsy, 5-HTP-induced hyperkinesis, 1- (thietanyl-3) imidazoles

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