SOME EPIDEMIOLOGICAL ASPECTS OF NEW CORONAVIRUS INFECTION COVID-19, DEFINING THE ACTIONS OF PREVENTIVE AND ANTI-EPIDEMIC DIRECTIONS

This review contains information on the SARS-CoV-2 virus, its resistance to environmental factors, the gateway for the pathogen to enter the human body, the mechanisms and routes of transmission, age groups at risk of developing various forms of new coronavirus infection, and the epidemiological significance of various categories of sources of infection, which ensure the activity of the first link of the epidemic process, the principles of selection and rational use of personal protective equipment in conditions of the epidemiological risk of the spread of the new coronavirus infection COVID-19. This information indicates the need for integrated interactions of various areas of scientific research, giving objectification of the development processes of the incidence of the new coronavirus infection COVID-19. The results of scientific research in a complex epidemiological situation are of a pronounced applied nature, which ensures the formation and optimization of the epidemiological surveillance system for the new coronavirus infection and determines the vector of studying a wide range of issues related to ensuring the epidemiological safety of the population. It is concluded that it is necessary to continue multidirectional research in order to solve multiple applied questions that ensure the optimization of the epidemiological surveillance system in all subsystems and determine the vector of effective management of the epidemic process.

new coronavirus infection COVID-19, virus resistance, mechanism of transmission, routes of transmission, sources of infection, risk groups, epidemiological surveillance

1. Бета-коронавирусы человека и их высокочувствительная детекция с помощью ПЦРипрочих методов амплификации / Р.Р. Гарафутдинов [и др.] // Биомика. - 2020. - Т.12(1). - С. 121-179

2. Левакова, И.А. Эпидемиологическая характеристика хронических вирусных гепатитов в РФ в 1999-2009 гг. / И.А. Левакова, С.Л. Мукомолов // Инфекция и иммунитет. - 2011. - Т. 1, №3. - С. 255-262

3. Намазова-Баранова, Л.С. COVID-19 и дети / Л.С. Намазова-Баранова, А.А. Баранов // Пульмонология. - 2020. - № 30 (5). - С. 609-628

4. Тенденции развития эпидемического процесса вирусных гепатитов в Республике Башкортостан / Т.В. Кайданек [и др.] // Здоровье населения и среда обитания. - 2017. - № 12 (297). - С. 34-36

5. Эпидемический процесс COVID-19 в Российской Федерации: промежуточные итоги. Сообщение 2. [Электронный ресурс] / Н.Ю. Пшеничная [и др.] // COVID19-PREPRINTS.MICROBE.RU. - 2020.URL: https://doi.org/10.21055/preprints-3111778 (дата обращения: 01.12.2020)

6. A public health emergency of international concern over the global outbreak of novel coronavirus declared by WHO. Available at: https://www.who.int/dg/speeches/detail/whodirectorgeneral-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov)

7. Blanco-Melo D., Nilsson-Payant B.E., Liu W.-C., Uhl S., Hoagland D., Mоller R.,Jordan T. X., Oishi K.,Panis M., Sachs D., Wang T.T., Schwartz R.E., Lim J.K., AlbrechtR.A.,ten Oever B.R. Imbalanced host responsetoSARS-CoV-2 drives development of COVID-19. Journal pre-proof Cell Press 2020.04.026.DOI: 10.1016/j.cell.2020.04.026

8. Caruso D, Zerunian M, Polici M, [et al.] Chest CT Features of COVID-19 in Rome, Italy. Radiology. 2020;296(2):E79-E85. DOI: 0.1148/radiol.2020201237

9. Chen Z.M., Fu J.F., Shu Q. et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J. Pediatr. 2020; 16 (3):240-246. DOI: 10.1007/s12519-020-00345-5

10. Chia P.Y., Coleman K.K., Tan Y.K. et al. Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients Singapore 2019 Novel Coronavirus Outbreak Research Team. Nat. Commun. 2020; 11 (1): 2800.DOI: 10.1038/s41467-020-16670-2

11. Cui Y., Tian M., Huang D. et al. A 55-day-old femalein fant infected with COVID 19: Presenting with pneumonia,liver injury, and heart damage. J. Infect. Dis. 2020; 221(11): 1775-1781. DOI: 10.1093/infdis/jiaa113

12. Derek K Chu, Elie A Akl, Stephanie Duda, Karla Solo, Sally Yaacoub, Holger J. Physical distancing, facemasks, andeyeprotectionto-preventperson-to-persontransmissionofSARS-CoV-2 andCOVID-19: asystematic review and meta-analysis. Lancet 2020; 395: 1973- 87Published Online June 1, 2020 https://doi.org/10.1016/ S0140-6736(20)31142-9

13. DongL.,TianJ., HeS. Etal.Possible vertical transmission ofSARS-CoV-2 from an infected mother to her newborn.JAMA.2020; 323 (18): 1846-1848. DOI: 10.1001/jama.2020. 4621

14. Gao Z, Xu Y, Sun C, et al. A Systematic Review of Asymptomatic Infections with COVID-19. J Microbiol Immunol Infect.2020;10.1016/j.jmii.2020.05.001. doi:10.1016/j.jmii.2020.05.001

15. Gemmati D., Bramanti B., Serino M.L. etal.COVID-19 and individual genetic susceptibility/receptivity: Role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in females be protective against SARS-CoV-2 compared to the single X- chromosome in males? Int. J. Mol. Sci. 2020; 21 (10):3474. DOI: 10.3390/ijms21103474

16. Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S.,Schiergens T.S., Herrler G., Wu N.H., Nitsche A., Müller M.A., Drosten C., öhlmann S. SARSCoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.PMID: 32142651

17. Holshue M.L., DeBolt C., Lindquist S. et al. First case of2019 novel coronavirus in the United States. N. Engl. J. Med.2020; 382 (10): 929-936. DOI: 10.1056/NEJMoa2001191

18. Hosoki K, Chakraborty A, Sur S. Molecular mechanisms and epidemiology of COVID-19 from an allergist's perspective. J Allergy Clin Immunol.2020;S0091-6749(20)30799-5. doi:10.1016/j.jaci.2020.05.033

19. Huff HV, Singh A. Asymptomatic transmission during the COVID-19pandemic and implications for public health strategies. ClinIn- fectDis.2020;ciaa654. doi:10.1093/cid/ciaa654

20. Ji L.N., Chao S., Wang Y.J. et al. Clinical features of pediatric patients with COVID-19: a report of two family claster cases. World J. Pediatr. 2020; 16 (3): 267-270. DOI: 10.1007/s12519-020-00356-2

21. Kam K.Q., Yung C.F., Cui L. et at. A well infant with coronavirus disease 2019 (COVID-19) with high viral load. Clin. Infect. Dis. 2020; 71 (15): 847-849. DOI: 10.1093/cid/ciaa201

22. Lackey K.A., Pace R.M., Williams J.E. SARS-CoV-2 and human milk: What is the evidence? Matern. Child Nutr.2020;e13032.[Preprint.Posted: 2020, May 30].DOI: 10.1111/mcn.13032

23. Li G., Fan Y., Lai Y., Han T., Li Z., Zhou.P, Pan P., Wang W., Hu D.,Liu X., ZhangQ., WuJ. Coronavirusinfectionsandimmuneresponses. J MedVirol. 2020;92(4):424-32 DOI: 10.1002/jmv.25685

24. Li Y., Zhao R., Zheng S. et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China.Emerg. Infect. Dis. 2020; 26 (6): 1335-1336. DOI: 10.3201/eid2606.200287

25. Liu W., Zhang Q., Chen J. et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N. Engl. J.Med. 2020; 382 (14): 1370-1371. DOI: 10.1056/NEJMc2003717

26. Lu Q., Shi Y. Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. J. Med. Virol. 2020;92 (6): 564-567. DOI: 10.1002/jmv.25740.124

27. National Health Commission of the People’s Republic of China. Update onCOVID-19 in China as of 24th hour on April 7, 2020. Beijing, China: National Health Commission; 2020

28. Oran DP, Topol EJ. Prevalence of Asymptomatic SARS-CoV-2 Infection: ANarrative. Ann Intern Med. 2020; M20-3012. doi:10.7326/M20-301210

29. Ou X., Liu Y., Lei X., Li P., Mi D., Ren L., Guo L., Guo R., Chen T., Hu J., Xiang Z., MuZ., ChenX., ChenJ., HuK., JinQ., WangJ., QianZ. CharacterizationofspikeglycoproteinofSARS-CoV-2. On virus entry and it simmune cross-reactivity with SARS-CoV. Version 2. Nat Commun. 2020 Mar 27;11(1):1620. doi: 10.1038/s41467-020-15562-9. PMID: 32221306

30. Park J.Y., Han M.S., Park K.U. et al. First pediatric case of coronavirus disease 2019 in Korea. J. Korean Med. Sci. 2020; 35 (1): e124. DOI: 10.3346/jkms.2020.35.e124

31. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020;38(1):1-9. DOI: 10.12932/AP-200220-0772

32. Qiu H. Wu J., Hong L. et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect. Dis. 2020; 20 (6): 689-696. DOI:10.1016/S1473-3099(20)30198-5

33. Rahimzadeh G., Noghabi M.E., Elyaderani F.K. etal.COVID-19 infection in Iranian children: A case series of 9 patients. J. Pediatr. Rev. 2020; 8 (2): 139-144. DOI: 10.32598/jpr.8.2.139

34. Van Doremalen N., Bushmaker T., Morris D.H. et al. Aerosol and surface stability of SARS-CoV-2 as comparedwith SARS-CoV-1. N. Engl. J. Med. 2020; 82 (16): 1564-1567. DOI: 10.1056/NEJMc2004973

35. Wei L, Lin J, Duan X, et al. Asymptomatic COVID-19 Patients Can Contaminate Their Surroundings: an Environment Sampling Study.mSphere. 2020;5(3):e00442-20. doi:10.1128/mSphere.00442-20

36. West R., Michie S., Rubin G.J., AmlÔt R. Applying principles of behave our changet or educeSARS-CoV-2 transmission. Nat. Hum. Behav. 2020; 4 (5): 451-459. DOI: 10.1038/ s41562-020-0887-9

37. WölfelR., CormanV.M., GuggemosW., SeilmaierM., ZangeS., MüllerM.A., NiemeyerD., JonesT.C., VollmarP., RotheC., HoelscherM., BleickerT., BrüninkS., SchneiderJ., EhmannR., ZwirglmaierK., DrostenC., WendtnerC.Virological assessment of hospitalized patients withCOVID-2019 // Nature. 2020. doi: 10.1038/s41586-020-2196-x

38. Wu Z, McGoogan JM. Asymptomatic and Pre-Symptomatic COVID-19 inChina. Infect Dis Poverty. 2020;9(1):72.doi:10.1186/s40249-020-00679-2

39. Xu Y., Li X., Zhu B. etal.Characteristics of pediatric SARSCoV-2 infection and potential evidence for persistent fecalviral shedding. Nat. Med. 2020; 26 (4): 502-505. DOI:10.1038/s41591-020-0817-4

40. Yang Z., Liu Y. vertical transmission of severe acute respiratory syndrome coronavirus 2: A systematic review. Am. J.Perinatol. 2020; 37 (10): 1055-1060. DOI: 10.1055/ s-0040-1712161

41. Young B.E., Ong S.W., Kalimuddin S. et al. Epidemiologic features and clinical course of patients infected with SARSCoV-2 in Singapore.JAMA. 2020; 323 (15): 1488-1494.DOI: 10.1001/jama.2020.3204

42. Yu X, Yang R. COVID-19 transmission through asymptomatic carriers is achallenge to containment. Influenza Other Respir Viruses. 2020;14(4):474-475. doi:10.1111/irv.12743

43. Zeng H., Хu С., Fan J. etal. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020; 323 (18):1848-1849. DOI: 10.1001/jama.2020.4861

44. Zhou P., Yang X., Wang X. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270-273. DOI: 10.1038/s41586-020-2012-7

45. Zhu H., Wang L., Fang C. et al. Clinical analysis of 10 neonatesborn to mothers with 2019-nCoV pneumonia. Transl.Pediatr. 2020; 9 (1): 51-60. DOI: 10.21037/tp.2020.02.06