EVALUATION OF EPSTEIN-BARR VIRUS PROTEIN EXPRESSION IN CELLS OF NASAL POLYPS

Abstract

Given the wide prevalence of Epstein-Barr virus (EBV) infection and the ability of the virus to infect nasopharyngeal cells, the goal was to determine the role of EBV investigate the expression of EBV proteins in the tissues of nasal polyps in nonallergic polypous rhinosinusitis (NAPR).Material and methods. A study of 20 nasal polyps obtained during polypectomy in patients with intolerance to nonsteroidal antiinflammatory drugs (NSAIDs) was conducted. The expression of Epstein-Barr virus proteins was evaluated by immunohistochemistry. Statistical assessment was conducted using basic software package «Microsoft Excel 2007», «Statistica 6.0».Results. Specific EBV proteins were found in all the studied nasal polyps. LMP 1-protein was detected in 76% of polyps, most epithelial cells did not express this protein. The PE2 protein was expressed in many epithelial cells (in 80% of cases) and inflammatory cells (in 64% of cases). The EBI3 protein was detected mainly in the cytoplasm of lymphocytes (in 65% of cases).Conclusion: In NAPR, the leading is the inflammatory endotype of polyps with a predominance of the fibroedematous component. In the cells of nasal polyps with NSAID-induced pathology, EBV proteins are expressed in 100% of cases. LMP1 and BI3 proteins are detected mainly in inflammatory cells, while PE2 protein is detected in epithelial and stromal cells.