ELECTROENCEPHALOGRAPHIC CONTROL OF WEST SYNDROME TREATMENT
Abstract
Aim: to compare electroencephalogram (EEG) changes in the treatment of West syndrome (WS) with and without tetracosactide.Material and methods. In 150 patients with WS, EEG was evaluated before and 6 months after the start of treatment. Group I consisted of 90 children who received tetracosactide for the relief of infantile spasms, and group II included 60 children who were treated with any other antiepileptic drugs without the use of hormones. Indicators of the risk ratio were calculated using the RevMan5.3 program. Favorable treatment outcomes were considered: clinical remission-relief of seizures and the disappearance of hypsarrhythmia on the EEG.Results. After 6 months from the start of treatment, seizures in group I were arrested in 77%, and in group II - in 60%, p = 0.04.In group I, after 6 months from the start of treatment, changes in the EEG in the form of hypsarrhythmia remained in 3% of patients who had hypsarrhythmia before treatment, while in group II hypsarrhythmia persisted in 20%, p = 0.02.Conclusions. Treatment of WS with the inclusion of tetracosactide is more effective in reducing hypsarrhythmia and infantilespasms than therapy without it.
About the Authors
M. E. Farnosova
ГАУЗ «Детская городская больница № 8 им. А.Ю. Ратнера»
Russian Federation
Russian Federation
R. G. Gamirova
ГАУЗ «Детская городская больница № 8 им. А.Ю. Ратнера»; КГМА - филиал ФГБОУ ДПО РМАНПО Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Farnosova M.E., Gamirova R.G. ELECTROENCEPHALOGRAPHIC CONTROL OF WEST SYNDROME TREATMENT. Bashkortostan Medical Journal. 2021;16(2):28-33. (In Russ.)
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