REFERENCE AND OPERATIVE SPATIAL MEMORY OF RATS BROOD WITH MERCAZOLYL HYPOTHYROIDISM AND CORRECTIONOF HYPOTHYROIDISM WITH IODINE SACCHARIDE COMPLEX

The aim of this work is to study the reference and operational spatial memory of animals brood with experimental hypothyroidism and to evaluate the effectiveness of hypothyroidism correction with a new iodinesaccharide complex.The object of the study: two-month-old male rats - the offspring of rats with hypothyroidism (mercazolyl intragastrically 2.5 mg /100 g body weight for 21 days) (experimental group), some of which were on a general food ration for 30 days before mating (comparison group), and some on iodine-enriched - received iodine-saccharide complex iodosteviol glycoside rebaudioside A 2.5 μg iodine / 100 g body weight (main group). In blood plasma, the levels of thyroidstimulating hormone, total and free thyroxine, and total triiodothyronine were determined by enzyme immunoassay. To assess the spatial learning and memory of animals we used thetest «Eight-arm radial maze».The results of the studies showed that mercazolyl hypothyroidism in parents of experimental animals negatively affects the thyroid hormone genesis of the offspring, causes the development of impaired operative and long-term memory, significantly reducing the average score at the testing stages. In the offspring of rats that underwent a 30-day recovery period on general food, the level of thyrotropin in the blood plasma remained elevated, and the level of free thyroxine decreased, indicating the persistence of hypothyroidism. Keeping animals on an iodine-enriched diet promoted the restoration of the functional activity of the thyroid gland in the offspring and an improvement in the indices of reference and operational spatial memory.

experimental hypothyroidism, thyrotropin, thyroxine, triiodothyronine, reference and operative memory, iodinesaccharide complex

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