COMPARATIVE SAFETY OF THE OF ANTIEPILEPTIC DRUGS

Abstract

Purpose - to analyze the frequency of adverse drug reactions of various antiepileptic drugs (AEDs) depending on the lesion of a certain organ system in adults and children with epilepsy.Material and methods. Treatment of 428 patients with epilepsy was analyzed.Results and conclusions. Out of 359 adverse drug reactions with the nervous system damage recorded in our study with the use of all antiepileptic drugs, 28.0% of side effects were associated with the gastrointestinal tract (GIT) damage, 21.0% of the hepatobiliary system damage and 20.0% - with metabolic disorders. CNS damage was more common in patients taking carbamazepine (45%) and oxcarbazepine (44%). Adverse drug reactions (ADRs) associated with disorders of the gastrointestinal tract and hepatobiliary system were more common when taking levetiracetam (29.4%), carbamazepine (28.9%) and oxcarbazepine (22.2%). Metabolic disorders were more often detected when taking topiramate (34.8%). Side effects with impaired blood system were often associated with taking levetiracetam (17.6%), valproate (16.3%) and carbamazepine (11.8%). The most frequently caused allergic reactions were lamotrigine (23%) and ethosuximide (33%). This study showed that patients taking AEDs require regular follow-up monitoring (monitoring of blood counts, ultrasound of internal organs, examination by a psychologist and psychotherapist).