CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF IXODIC TICK-BORNE BORRELIOSIS IN THE SAMARA REGION

Abstract

Purpose. Determination of clinical and epidemiological features of ixodic tick-borne borreliosis in the Samara region.Material and methods. The data of the FBHI "Hygienic and Epidemiological Center in the Samara Region" for the period 2004-2019 were analyzed on the incidence of tick-borne borreliosis. A retrospective analysis of 155 cases of tick-borne borreliosis in patients with mild and moderate severity of the disease was carried out.Results. Over the past 12 years, in the Samara region, an increase of tick suction has been recorded by 3 times, an increase in borrelia infection of ticks of the genus Ixodes up to 1.8%. Ixodic tick borreliosis was observed both in forest zones and within thecity from May to October. Asthenic-vegetative syndrome, erythema, fever and regional lymphadenitis prevailed in patients with ix-odic tick-borne borreliosis in the region. Erythema-free form of ixodic tick-borne borreliosis in comparison with erythema is characterized by an acute onset of the disease with high fever, intoxication, severe asthenic, dyspeptic and statistically significant frequent myalgic syndromes. An increase of the inflammation level markers (CPK and CRP) revealed in patients of the compared groups, and in the group with an erythema-free form of ixodic tick-borne borreliosis, an increase of the level and marker of tissue damage (LDH) indicate the development of systemic inflammatory syndrome and organ damage.Conclusions. The unfavorable situation in the natural foci of ixodic tick-borne borreliosis on the territory of the region remains,which is confirmed by the annual findings of markers of pathogenic borrelia in ixodid ticks and an increase in the number of people who turn up for tick suction in health care institution (HCI). Clinical and laboratory differences between erythema and nonerythema forms of the disease were revealed.