PECULIARITIES OF THE CLINICAL COURSE OF HEREDITARY OVARIAN CANCER

Abstract

This article presents the results of our own study of the main clinical signs characteristic of hereditary ovarian cancer (НОС).Material and methods. The selection of patients for the study was carried out by means of a questionnaire in order to identify persons with suspected hereditary nature of the disease. A standard diagnostic panel of DNA, widespread in Russia, intended for the diagnosis of ovarian and breast cancer, was used as an HOC diagnosis. Additionally, targeted sequencing of a new generation wascarried out in patients with negative PCR (polymerase chain reaction) results.Results and discussion. The most significant clinical signs of HOC were: the age of manifestation, the presence of a burdened family and personal cancer history. HOC is significantly more common (p = 0.028) in middle-aged people. The average age of onset of the tumor process was 52.95±11.28 years. HOC is characterized by a burdened family history, and having relatives of the 1st degree of relationship with an oncological history is significantly more in the group of patients with identified germline disorders than in the group without them (p = 0.00033). Malignant neoplasms in relatives by blood in the main group, on average, developed 9 years earlier than in the comparison group (U = 86.5, P = 0.004). The histological subtype specifically attributed to HOC is serous low-grade, endometrioid and undifferentiated carcinomas, but not mucinous ovarian carcinoma, which is more peculiar to ovarian cancer of a non-hereditary nature of the disease.Conclusion. HOC is characterized by an earlier age of onset of the tumor process, a burden of family and personal history.