GENOTYPIC CHARACTERISTICS OF PATIENTS WITH ALOPECIA AREATA UNDER EXPOSURE TO CHEMICAL ENVIRONMENTAL FACTORS

Abstract

It is known that in industrial city the priority pollutants are formaldehyde, lead, nitrogen dioxide contained in the atmospheric and lead, nickel, manganese and chromium in water and soil, which are likely to contribute to the phenotypic manifestations of genetically determined diseases. In the context of the effects of these pollutants, in individuals with polymorphic markers rs1024161 CTLA4 gene, rs694739 PRDX5 gene, rs1701704 IKZF4 gene, rs10760706 STX17 gene phenotypic realization of genetic polymorphism with alopecia areata (AA) development occurs. The largest contribution to the association with the phenotype of GA is shown by genotype G/G rs10760706 STX17 gene genotype A/A rs1024161 CTLA4 gene, according to the major allele homozygote A rs694739 gene PRDX5, genotype G/A and G/G rs1701704 IKZF4 gene. These polymorphic markers may be regarded as biomarkers of sensitivity to anthropogenic influences in people genetically predisposed to AA. To prove gene-environment interaction there is a need for further investigation using math modelling methods.