EXPERIMENTAL SUBSTANTIATION OF THE USE OF A COMBINATION OF MESH POLYPROPYLENE PROSTHESIS AND MESENCHYMAL STEM CELLS FOR THE TREATMENT OF GENITAL PROLAPSE

Abstract

Postoperative complications in the treatment of genital prolapse in the form of pain syndrome and mucosal erosions when using mesh prostheses cause the development of alternative materials for the correction of genital prolapse.The aim of the study was to evaluate multipotent mesenchymal stem cells (MMSCs) in combination with a mesh prosthesis in vivo.Material and methods. 32 Sprague Dawley rats in the experiment were damaged by the posterior vaginal wall, followed by the use of MMSC in combination with a mesh prosthesis, and in the control group healing occurred only with the use of a mesh implant.Results and discussion. As a result of the experiment (on the 30th day) in the experimental group of rats after the use of MMSC, the restored vaginal mucosa of rats was quite intensively supplied with blood vessels, and on the 7th day the wound was epithelizedand granulation tissue was found under it. The use of MMSC led to complete epithelization of the wound and the formation of a structurally complete connective tissue plate of the mucous and submucosal membranes.Conclusion. The use of autologous multipotent mesenchymal stem cells in pelvic floor reconstruction can significantly improvethe results of reconstructive operations.