ELECTRON MICROSCOPIC STUDY OF THE WAG/RIJ LINE RATS RETINA- EXPERIMENTAL MODEL OF RETINITIS
Abstract
The aim of the study is to identify the features of the ultrastructural organization of the WAG/Rij rats retina.Material and methods. The retinas of WAG/Rij rats, which are an experimental model of retinitis pigmentosa, have been studied by electron microscopic methods from birth to maturity.Results and discussion. Certain patterns of structural changes in the retina have been established as the animals grow older. By the end of the 3rd week after birth, ultrastructural signs of dystrophic and destructive processes begin to be determined in the retinaof rats, which intensify with age and lead to retinal degeneration.Conclusion. The early manifestation of signs of pathomorphological changes makes it possible to recommend WAG/Rij rats for experiments not only at puberty, but also at a young age, when an attempt can be made to treat the retina to prevent the development of degenerative disease.
About the Authors
L. A. Musina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. S. Baigildin
ФБУН «УфНИИ Медицины труда и экологии человека»; ФГБОУ ВО «Башкирский государственный университет» Минобрнауки России
Russian Federation
Russian Federation
O. V. Dyudbin
ФГБОУ ВО «Башкирский государственный аграрный университет» Минсельхоза Росси
Russian Federation
Russian Federation
I. F. Musin
ФГБОУ ВО «Башкирский государственный университет» Минобрнауки России
Russian Federation
Russian Federation
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Review
For citations:
Musina L.A., Baigildin S.S., Dyudbin O.V., Musin I.F. ELECTRON MICROSCOPIC STUDY OF THE WAG/RIJ LINE RATS RETINA- EXPERIMENTAL MODEL OF RETINITIS. Bashkortostan Medical Journal. 2021;16(5):32-35. (In Russ.)
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