OPHTHALMIC MANIFESTATIONS OF CHRONIC MYELOPROLIFERATIVE DISEASES

This article includes a literature review on the ophthalmic manifestations of chronic myeloproliferative diseases. Currently data of prevalence and clinical manifestations of damage of the visual organ of this group of hemoblastoses are insufficient and inconsistent. The article describes some variants of ophthalmic disorders in different eye structures in the pathology of blood. Leukemic infiltrates, hemorrhages, ischemic and infectious lesions and changes during treatment are found in patients with hemoblastosis in the eye tissues. Hemorrhagic syndrome is a basis of the majority of the ophthalmic manifestations in this group of hemoblastoses. Сhoreoretinal pathology prevails in chronic myeloproliferative diseases. The main methods of diagnostics of pathologies of posterior segment of eye are optical coherence tomography and optical coherence tomography with angiography. Various chemotherapeutic agents used in the treatment of chronic myeloproliferative diseases can have side effects on the organ of vision. All patients with this pathology are recommended for ophthalmological examination.

chronic myeloproliferative diseases, ophthalmic manifestations, leukemic infiltration, hemorrhagic syndrome, hemorrhage, vascular thrombosis, monoclonal antibodies, optical coherence tomography

1. Азнабаев Б.М. Оптическая когерентная томография + ангиография в диагностике, терапии и хирургии глазных болезней / Б.М. Азнабаев, Т.Р. Мухамадеев, Т.И. Дибаев. - М.: Август Борг, 2019. - 352 с

2. Гемобластозы. Особенности поражения глаз / Л.Ф. Руднева [и др.]. / под ред. И.В. Медведевой. - Тюмень: ИП Коновалов И.С., 2020. - 90 с

3. Гришина Е.Е. Офтальмологические проявления лейкоза / Е.Е. Гришина, А.О. Мамонтов // Альманах клинической медицины. - 2016. - Т. 44, №5. - С. 587-591

4. Клиническая онкогематология/ под ред. М.А. Волковой. - М., 2001. - С. 263-300

5. Румянцева, Ю.В.Оптимизация терапии острого лимфобластного лейкоза у детей в России и Белоруссии / Ю.В. Румянцева, А.И. Карачунский // Вопросы гематологии/онкологии и иммунопатологии в педиатрии. - 2007. - Т.6, №4. - С. 13

6. Чистякова, Н.В. Офтальмологические проявления лейкозов / Н.В. Чистякова // Офтальмологические ведомости. - 2016. - Т.9, №2. - С. 81-99

7. Чистякова, Н.В. Случай изолированного внутриглазного рецидива острого лимфобластного лейкоза / Н.В. Чистякова, Ф.Е. Шадричев, Т.И. Кузнецова // Офтальмологические ведомости. - 2017. - Т.10, №3. - С. 74-84

8. A novel OCT signature in leukemic papillopathy masquerading as autoimmune or infectious uveitis / JML Miller [et al.] // Graefes Arch. Clin. Exp. Ophthalmol. - 2021 Jan; doi: 10.1007/s00417-020-05055-2

9. A unique case of chronic myeloid leukemia presenting as monocular vision loss with unilateral retinopathy / M.P. Seraly [et al.] // American Journal of Ophthalmology Case Reports. - 14 (2019) 67-69

10. Abu el-Asrar A.M. Correlation of fundus lesions and hematologic findings in leukemic retinopathy / A. M. Abu el-Asrar, A. K. al- Momen, D.Kangave, // Eur. J.Ophthalmol. - 1996;6(2):167-172

11. Anterior chamber exudation in chronic myeloid leukaemia / R. Bypareddy [et al.] // BMJ Case Rep. 2016 Nov 28;2016:bcr2016217173.doi: 10.1136/bcr-2016-217173

12. Central retinal artery occlusion as a presenting manifestation of polycythaemia vera / K. Rao [et al.] // BMJ Case Rep. - 2016. doi: 10.1136/bcr-2016-216417

13. Chawla R. Panuveitis simulating ocular Behcet’s in cases of chronic myelogenous leukaemia in remission / R. Chawla, K. Tripathy // BMJ Case Rep. 2017: DOI: 10.1136 / bcr-2017-222238

14. Chronic myeloid leukemia as a secondary malignancy after lymphoma in a child / K. Zahra [et al.] // Oncology Research and Treatment. - 2012;35(11):690-693

15. Classification of retinal diseases based on OCT Images / N. Eladawi[et al.] // Front.Biosc. (Landmark Ed). - 2018;1;23:247-264

16. Clinical and imaging characteristics of orbital leukemic tumors / M. Bidar [et al.] // Ophthalmic. Plast. Reconstr. Surg. - 2007;23(2):87-93

17. Huang P.K., Sanjay S. / Visual disturbance as the first symptom of chronic myeloid leukemia // Middle East Afr. J.Ophthalmol. 2011;18:336-338

18. Imatinib mesylate (Gleevec) induced unilateral optic disc edema / C. DeLuca [et al.] // Optom. Vis. Sc. - 2012 Oct;89(10):e16-22

19. Imatinib-induced postoperative periorbital purpura: GASP (Gleevec-Associated Surgical Purpura) in a woman with imatinib-treated chronic myelogenous leukemia / C.L. Anzalone [et al.] // Dermatol. Online J. - 2014 Jan 15;20(1):21242

20. Jain A. Isolated CNS Blast Crises in Chronic Myeloid Leukaemia Presenting as Hypertrophic Pachymeningitis and Bilateral Optic Neuritis: A Case Report / A. Jain, N. Gupta //j. Clin. Diagn. Res. - 2016 Jan;10(1):OE01-5

21. JampolL.M. Peripheral retinal microaneurysms in chronic leukemia / L.M. Jampol, M.F. Goldberg, B. Busse // Am. J. Ophthalmol. - 1975 Aug;80(2):242-248

22. Kim M.J. Case of bilateral retinal neovascularization associated with chronic idiopathic myelofibrosis / M.J. Kim, H.G. Yu // Korean J. Ophthalmol. - 2010 Apr;24(2):131-133

23. Kleinman, R.A. Iridocorneal leukemic infiltrate in chronic myelogenous leukemia / R.A. Kleinman, B.P. Erickson, P.R. Egbert //j. Fr. Ophtalmol. 2019 Mar;42(3):341-343

24. Kumar V. Leukemic retinopathy and foveal infiltrates / V. Kumar, D.Kumawat, S.Dhakal// Int.Ophthalmol. - 2018 Jun;38(3):1301-1303

25. Leonardy NJ, Rupani M, Dent G, Klintworth GK. Analysis of 135 autopsy eyes for ocular involvement in leukemia. Am J. Ophthalmol. 1990;109(4):436-444

26. Lin A.L. Ocular manifestations of primary myelofibrosis / Lin Albert L, Jordan M. Burnham, Victor Pang // Retin Cases Brief. Rep. - 2016;10(4):364-367

27. Lukens J.N. / Acute lymphoblastic leukemia. Wintrobe´s Clinical Hematology // Eds. G.R.Lee et al. - London. - 1993. - P.1892

28. Ocular adverse events associated with antibody-drug conjugates in human clinical trials /j.S. Eaton [et al.] // Journal of ocular pharmacology and therapeutics 2015: 589-604

29. Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters /R. Dhasmana [et al.] // Ann. Afr. Med. - 2016;15:97-103

30. Ocular side effects in chronic myeloid leukemia patients treated with imatinib / M. Breccia [et al.] // Leukemia Research Volume 32, Issue 7, July 2008, Pages 1022-1025

31. Ocular Toxicity of Belantamab Mafodotin, an Oncological Perspective of Management in Relapsed and Refractory Multiple Myeloma / A. Wahab [et al.] //Oncol., 11 May 2021; doi.org/10.3389/fonc.2021.678634

32. Ophthalmologic Manifestations as Initial Presentation of Patients with Chronic Myeloid Leukemia: Report of Two Cases / S.F. Mohamed [et al.] // Case Rep. Oncol. - 2020;13:7-11

33. Orbital myeloid sarcoma secondary to acute myeloblastic leukemia / J-B Ducloyer [et al.] //j. Fr. Ophtalmol. - 2020 Jan;43(1):e15-e16

34. Peripheral retinal nonperfusion associated with chronic myeloid leukemia / S. Nobacht [et al.] // Am. J. Ophthalmol. - 2003 Mar;135(3):404-406

35. Persistent bloody tears as the initial manifestation of conjunctival chloroma associated with chronic myelogenous leukemia / S. Shah [et al.] // Graefes Arch. Clin. Exp. Ophthalmol. - 2013 Mar;251(3):991-992

36. Saleh S., Kaisra E., Danah A. Subjective intermittent color vision loss as an initial manifestation of chronic myeloid leukemia / S. Saleh,Е.Kaisra, А. Danah // American Journal of Ophthalmology Case Reports 19 (2020)

37. Vicini G. Leukostasis retinopathy with leukemic infiltrates as onset manifestation of chronic myeloid leukemia: a case report / G.Vicini, C. Nicolosi, D.Malandrino // European Journal of Ophthalmology 2020 May 31; doi: 10.1177/1120672120930679

38. Wechsler D.Z. Life-threatening haematological disorders presenting with ophthalmic manifestations / D.Z. Wechsler, T.S. Tay, D.L. McKay // Clinical and Experimental Ophthalmology 2004; 32: 534-550