FEATURES OF THE COURSE OF THE COVID-19 NEW CORONAVIRUS INFECTION IN RESIDENTS OF THE KABARDINO-BALKARIAN REPUBLIC

Purpose is to study the clinical and demographic features of the course of a new coronavirus infection in patients with a verified diagnosis of COVID-19
Material and methods. Clinical and demographic features of the course of a new coronavirus infection were studied in 308 patients hospitalized with a verified diagnosis of COVID-19 in the hospital of particularly dangerous infections in Nalchik from 04/14/2020 to 03/31/2021. Infection with SARS-CoV-2 was determined using the "CoV-2– Test" kit. Computed tomography of the lungs was performed at admission and in dynamics on the "ACTIVION 16-TS" device.
Results and discussion. Most patients were hospitalized late from the onset of infection, which negatively affected the outcome of the disease. A high prevalence of cardiovascular diseases among patients with COVID-19 (59.1%) was also revealed. The inhospital mortality rate averaged 7.3%; in the studied cohort of comorbid patients, it ranged from 25.5% to 59.8%, depending on the timing of admission to the hospital. The structure of causes of death was dominated by pulmonary embolism (44%), acute respiratory distress syndrome (22%), acute kidney injury (20.6%).
Conclusion. The results obtained, indicating the presence of clinical and laboratory features of the course of COVID-19, depending on the timing of admission to the hospital and the structure of comorbidities, will optimize the tactics of providing medical care to patients with COVID-19 against the background of cardiovascular diseases at the hospital stage. 

1. Bazdyrev, E.D. Coronavirus infection a topical problem of the XXI century. / E.D. Bazdyrev // Complex problems of cardiovascular diseases. 2020; 9(2): 6-16. (In Russ)

2. Grinevich, V.B. Features of management of comorbid patients during a pandemic of a new coronavirus infection (covid-19). // Cardiovascular therapy and prevention. 2020;19(4): 135-172. (In Russ)

3. Shlychto, E.V. Guide to the diagnosis and treatment of diseases of the circulatory system (BSK) in the context of the pandemic COVID19 / E.V. Shliachto, A.O. Konrody, S.V. Villavelde // Russian Cardiological Journal. 2020;25(3): 129-148. (In Russ)

4. Larina, V.N. Effect of coronavirus infection (covid-19) on the cardiovascular system. / V.N. Larina, M.G. Golovko, V.G. Larin / Bulletin RGMU. 2020;(2): 5-13. (In Russ)

5. Livzan, M.A. Ambulatory medical care algorithms for adult patients with a new coronavirus infection (COVID-19) and suspicion. / M.A. Livzan et al. // Cardiovascular therapy and prevention. 2021;20(4):42-46. (In Russ) https://doi.org/1015829/1728-88002021-2916

6. CHazova, I.E. COVID-19 i serdechno-sosudistye zabolevaniya. / I.E. CHazova, O.YU. Mironova // Terapevticheskij arhiv. 2020;92(9):4-7. (In Russ)

7. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii (COVID-19): Vremennye metodicheskie rekomendacii, versiya 5 ot 08.04.2020 g., g. Moskva, 2020.

8. Profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii (COVID-19): Vremennye metodicheskie rekomendacii, versiya 11 ot 07.05.2021 g., g. Moskva, 2021.https://doi.org/10.15829/1728-8800-2021-2916

9. Clinical characteristics of coronavirus disease 2019 in China / W.J. Guan [et al.] // N. Engl. J. Med. 2020;382(18): 1708-1720.

10. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis / W.J. Guan [et al.] // Eur. Respir. J. 2020;55(5): 2000547.