STUDY OF THE POSSIBILITY OF COMPLEX PROCESSING OF NIGELLA SATIVA L.
Abstract
The aim of the study: to study the chemical composition and antioxidant activity of the fatty oil and the aerial part of Nigella sativa L. to substantiate the development of resource-saving plant processing techniques.
Material and methods. The objects of the study were a commercial sample of Black cumin seed oil and the Nigella sativa L. herb grown in the Ulyanovsk region. The antioxidant activity of oil of black cumin was evaluated by registration of chemiluminescence in model systems in vitro. Phytochemical analysis of aqueous-alcoholic extracts from Nigella sativa L. herb was performed with direct and differential UV-spectrophotometry.
Results. Black cumin seed oil shows a significant inhibition of free radical oxidation processes in model systems: 6 times more active in the system generating the production of reactive oxygen species than the reference preparation (alpha-tocopherol acetate), and 2 times more active in the system of lipid peroxidation. Spectrophotometric analysis of extracts on 40/70/96% ethyl alcohol confirmed the presence of the sum of flavonoids in the herb of Nigella sativa L. A liquid dosage form was offered – Nigella sativa L. 70% ethanolic herb tincture (1:5).
Conclusions. The obtained data show the potential of all raw materials of Nigella sativa L. for the complex and rational use of the plant potential in medicine and pharmacy.
About the Authors
A. R. Mubinov
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
E. V. Avdeeva
ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
G. M. Latypova
ФГБОУ ВО «Башкирский медицинский государственный университет» Минздрава России
Russian Federation
Russian Federation
Y. L. Bortsova
ФГБОУ ВО «Башкирский медицинский государственный университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Mubinov A.R., Avdeeva E.V., Latypova G.M., Bortsova Y.L. STUDY OF THE POSSIBILITY OF COMPLEX PROCESSING OF NIGELLA SATIVA L. Bashkortostan Medical Journal. 2022;17(6):33-37. (In Russ.)
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