REVIEW OF APPROACHES TO STANDARDIZATION OF MEDICINAL PLANT RAW MATERIALS CONTAINING BIOLOGICALLY ACTIVE SUBSTANCES OF PHENOLIC AND TERPENOID NATURE

Abstract

There was a comparative study carried out regarding the approaches to the standardization of medicinal plant raw materials and medicinal herbal preparations in the State Pharmacopoeia of the Russian Federation of the XIV edition and the European Pharmacopoeia of the 10th edition. The main differences in the identification and determination of the quantitative content of biologically active compounds in medicinal plant raw materials in Russia and the European Union have been provided. Substances of reference standards used in both pharmacopoeias are not present in the studied objects, especially when conducting a qualitative analysis. The increasing role of reference standards in modern pharmaceutical analysis has been confirmed. To ensure the quality, efficacy and safety of herbal medicines when used in medical practice, the need for a systematic approach to their standardization was shown, which will allow establishing scientifically based standards for the content of biologically active compounds in herbal raw materials and preparations. In this regard, it is necessary to provide the unification of methods for identifying and quantifying of biologically active compounds using modern instrumental methods of analysis.