WOUND HEALING ACTIVITY OF EXPERIMENTAL GELS BASED ON 4-R-2-HYDROXY-4-OXO-2-BUTENIC ACID HETERYLAMIDES

Abstract

Purpose: development of experimental gels based on 4-R-2-hydroxy-4-oxo-2-butenic acid heterylamides and study of their wound-healing effect on an in vivo model. Material and methods. Experimental semi-solid dosage forms based on a hydrophilic ointment base Macrogol 400 - Macrogol1500 (4:1), containing 4-R-2-hydroxy-4-oxo-2-butenoic acid hetarylamides as active components, which have a pronounced combined antibacterial, antifungal and anti-inflammatory action. The effect on the healing of linear aseptic skin wounds was studied by the method of wound-tensiometry.Results and discussion. The wound healing activity of the hydrophilic ointment base Macrogol 400 - Macrogol 1500 (4:1), ointment «Levomekol» and 3 prototypes of ointments was studied. It was found that two ointment compositions have a woundhealing effect compared to the control, their action is comparable to the activity of the reference drug and does not inhibit the processes of reparative regeneration in animals. An experimental gel exceeding the indicators of the comparison drug was found, which indicates the prospects for further study of derivatives of amides of α-oxocarboxylic acids.