INCRUSTING CYSTITIS AND PYELITIS AS SEVERE COMPLICATIONS AFTER KIDNEY TRANSPLANTATION
Abstract
Objective is to analyze the prevalence, clinical manifestations, diagnostic features and outcomes of incrusting cystitis and pyelitis (IC and IP, respectively) in patients with kidney transplantation according to the literature.
Material and methods. Russian and foreign literature in Russian and English was searched in Medline/PubMed, RSCI/Elibrary, CyberLeninka, Google Scholar databases. The analysis included journal articles, literature reviews, original studies, and clinical cases. Materials from conference proceedings, abstracts, dissertations, textbooks, and training manuals were not considered. Since IC and IP are rare conditions, the search covered the works published from 1992 to 2022.
Conclusions. Renal transplant recipients should be considered a high-risk group for the development of an incrusting urinary tract infection due to Corynebacterium urealyticum. The outcome of these diseases is difficult to predict, so the diagnosis of IC and IP should be made as soon as possible. Untimely or inadequate treatment in patients who underwent kidney transplantation is highly likely to result in graft loss.
About the Authors
S. V. PopovRussian Federation
R. G. Guseinov
Russian Federation
I. A. Miloserdov
Russian Federation
Yu. V. Kisil
Russian Federation
D. A. Sajdulaev
Russian Federation
S. V. Sadovnikov
Russian Federation
E. V. Pomeshkin
Russian Federation
K. V. Sivak
Russian Federation
V. V. Perepelitsa
Russian Federation
A. S. Ulitina
Russian Federation
References
1. González-Enguita C., Vela-Navarrete R. Corynebacterium urealyticum: historical significance of its discovery. Actas Urol Esp. 2017;41(2):140 [In Spanish, English abstract]. doi: 10.1016/j.acuro.2016.04.010.
2. Morales J.M. [et al.]. Alkaline pyelitis/cystitis and urinary tract infection caused by Corynebacterium urealyticum: a new severe complication after kidney transplantation. Transplant Proc. 1992; 24:81-82.
3. Van de Perre E. [et al.]. Incrustated uropathy: a comprehensive review to the base of the cortex. Frontiers in Medicine. 2021; 7: 609024. doi: 10.3389/fmed.2020.609024.
4. Sánchez-Martín F.M., López-Martínez J.M., Kanashiro-Azabache A. Corinebacterium urealyticum: increased frequency of infection and incrusted uropathy. Actas Urol Esp. 2016; 40:102-107. doi: 10.1016/j.acuro.2015.09.007.
5. Sinyakova L.A. [et al]. Incrustating cystitis in men. Consilium Medicum. 2016;18 (7): 27-29. Sinyakova L.A. [et al.]. Inkrustiruyushchiy tsistit u muzhchin. Consilium Medicum. 2016;18 (7): 27-29. [In Russ, English abstract].
6. Aguado J.M. [et al.] Encrusted pyelitis and cystitis caused by Corynebacterium urealyticum (CDC group D2): a new and threatening complication after kidney transplantation. Transplantation. 1993; 56(3): 617-22. doi: 10.1097/00007890-199309000-00023.
7. Nebreda-Mayoral T., Muñoz-Bellido J.L., Garcia-Rodríguez J.A. Incidence and characteristics of urinary tract infections caused by Corynebacterium urealyticum (Corynebacterium group D2). Eur J Clin Microbiol Infect Dis. 1994; 13:600-604. doi: 10.1007/BF01971313.
8. Hertig A., Duvic C., Chretien Y. Encrusted pyelitis of native kidneys. J Am Soc Nephrol. 2000; 11: 1138-1140. doi: 10.1681/ASN.V1161138.
9. Spears K, Hutton R, Amer T. Successful treatment of a case of extensive alkaline native kidney pyelitis. Journal of Clinical Urology. 2017; 10(1): 80-82. doi: 10.1177/20514158145393.
10. Tauch A., Trost E., Tilker A. The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing. J Biotechnol. 2008;136: 11-21. doi: 10.1016/j.jbiotec.2008.02.009.
11. Noël N, Rieu P. Infectious urinary lithiasis. EMC-Urologie. 2013; 6:1-8. doi:10.1016/S1762-0953(13)60343-X.
12. Del Prete D. [et al.] Encrusted cystitis by Corynebacterium urealyticum: a case report with novel insights into bladder lesions. Nephrol Dial Transplant. 2008;23(8):2685-7. doi: 10.1093/ndt/gfn243.
13. Fontana I. [et al.] Corynebacterium urealyticum infection in a pediatric kidney transplant recipient: case report. Transplant Proc. 2010;42(4):1367-8. doi: 10.1016/j.transproceed.2010.03.054.
14. Vázquez V., Morales M.D., Serrano C. Corynebacterium urealyticum in kidney transplantation. CT and sonographic imaging characteristics of incrusted cystitis and pyelitis. Nefrología. 2004; 24: 288-293. [In Spanish, English abstract].
15. Lieten S., Schelfaut D., Wissing K.M. Alkaline pyelitis and cystitis: an easily missed and life-threatening urinary infection. BMJ Case Rep. 2011;2011. doi: 10.1136/bcr.12.2010.3613.
16. Gadzhiev N.K. [et al] The problem of clinical diagnosis and treatment of incrusting cystitis. Urology. 2022; 5:142-146. Gadzhiev N.K. [et al.] Problema klinicheskoy diagnostiki i lecheniya inkrustiruyushchego tsistita. Urologiya. 2022; 5:142-146. [In Russ, English abstract].
17. Sakhi H., Adjaoud D., Hennequin C. A case study. Acute kidney injury, flanking pain, and calcifications in the kidneys in an 80-year-old woman. Kidney Int. 2018; 93: 527-528. doi: 10.1016/j.kint.2017.08.017. [In Spanish, English abstract].
18. Salem N., Salem L., Saber S. Corynebacterium urealyticum: a comprehensive review of an underestimated organism. Infect Drug Resist. 2015; 8: 129-145. doi: 10.2147/IDR.S74795.
19. García Bravo M. [et al.] Corynebacterium urealyticum en pacientes con transplante renal [Corynebacterium urealyticum in kidney transplant patients]. Med Clin (Barc). 1995; 104(15): 561-4. [In Spanish, English abstract].
20. Meria P., Jungers P. Incrusted pyelitis: an undiagnosed condition? Nephrol Dial Transplant. 2000; 15: 943-945. doi: 10.1093/ndt/15.7.943.Lopez-Medrano F. [et al] Urinary tract infection caused by Corynebacterium urealyticum in renal transplant recipients: undiagnosed etiology of obstructive uropathy and graft dysfunction: results of a prospective cohort study. Clin Infect Dis. 2008; 46(6): 825-30. doi: 10.1086/528713.
21. Parmar K., Thakur A., Tyagi S. Alkaline-encrusting pyelitis, a rare catastrophic complication after CPNL leading to chronic renal failure. Indian J Urol. 2019; 35(3): 240-241. doi: 10.4103/iju.IJU_126_19.
22. Sakhi H. [et al.] Encrusted urinary tract infections due to Corynebacteria species. Kidney Int Rep. 2020; 6(1): 179-186. doi: 10.1016/j.ekir.2020.10.034.
23. Benoit G. [et al.] Installation of a ureteric stent with double pigtail for prevention of urological complications in renal transplantation: a prospective randomized trial. J Urol. 1996; 156: 881-884. doi: 10.1016/S0022-5347(01)65647-7.
24. Sigogne M. [et al.] Encrusted pyelitis in a kidney allograft. Kidney Int. 2020; 97(1): 217. doi: 10.1016/j.kint.2019.08.010.
25. Vázquez V. [et al.] Corynebacterium urealyticum en pacientes con trasplante renal. Imágenes características de la TC y ultrasonography de la cistitis y pielitis incrustante [Corynebacterium urealyticum in renal trasplantation. Characteristics of CT and sonographic imaging of incrusted cystitis and pielitis]. Nefrologia. 2004;24(3):288-93. [In Spanish, English abstract].
26. Audard V. [et al.] Fatal septic shock caused by Corynebacterium D2. Intensive Care Med. 2003; 29(8): 1376-9. doi: 10.1007/s00134003-1865-1.
27. Johnson M, Perkins SK, Livitt D. Alkaline pyelitis causing renal failure in a transplanted kidney: treatment with percutaneous nephrolithotomy and urine acidification. J Endourol Case Rep. 2020; 6(4): 435-437. doi: 10.1089/cren.2020.0183.
28. Devine P.A., Courtney A.E.. Alkaline-encrusted pyelitis in a renal allograft. Kidney Int Rep. 2018; 4(1): 174-177. doi: 10.1016/j.ekir.2018.08.012.
29. Ulker V., Celik O. Endoscopic, single-session treatment of encrusted, neglected ureteric stents. Medicina (Kaunas). 2019; 55(3): 58. doi: 10.3390/medicina55030058.
30. Yenicesu M. [et al.]. The long-forgotten fixed ureteric stent in a renal transplant patient. In Transplantation proceedings. 2004; 36(5): 1395-1397. doi: 10.1016/j.transproceed.2004.05.077.
31. Yenicesu M. [et al]. Long-forgotten fixed ureteric stent in a renal transplant patient. In Transplantation proceedings. 2004; 36(5): 13951397. doi: 10.1016/j.transproceed.2004.05.077.
32. Veltman Y. [et al.]. Percutaneous nephrolithotomy and cystolitholapaxis for a «forgotten» stent in a transplanted kidney: a case history and review of the literature. Clinical Transplantation. 2010; 24(1). 112-117. doi: 10.1111/j.1399-0012.2009.01133.x.
33. Bhuva S., Kennish S.J., Wah T.M. A forgotten fixed stent in a transplanted kidney: a case history. Cases Journal. 2009; 2(1): 1-4. doi: 10.1186/1757-1626-2-27.
34. Lee R. [et al.]. Successful treatment of encrusting cystitis and pyelitis with preservation of the renal graft. Transplantation. 2004; 78(2): 302-3. doi: 10.1097/01.tp.0000135140.12454.f4.
35. Meria P. [et al.]. Encrusted cystitis and pyelitis in children: an unusual condition with potentially severe consequences. Urology. 2004; 64(3): 569-573. doi: 10.1016/j.urology.2004.04.013.
Review
For citations:
Popov S.V., Guseinov R.G., Miloserdov I.A., Kisil Yu.V., Sajdulaev D.A., Sadovnikov S.V., Pomeshkin E.V., Sivak K.V., Perepelitsa V.V., Ulitina A.S. INCRUSTING CYSTITIS AND PYELITIS AS SEVERE COMPLICATIONS AFTER KIDNEY TRANSPLANTATION. Bashkortostan Medical Journal. 2023;18(1):96-103. (In Russ.)