COMPARATIVE CHARACTERISTICS OF A COMPLEX SPECTROFLUOROMETRIC INDICATOR OF HYPOXIA IN THE LIMBAL ZONE IN PATIENTS USING DOMESTIC AND FOREIGN PROSTAGLANDIN ANALOGUES IN THE TREATMENT OF PRIMARY OPEN-ANGLE GLAUCOMA

The purpose of the study is to conduct a comparative assessment of spectrofluorimetric indicators of the limbal zone in the treatment of patients with primary open-angle glaucoma with the drug latanoprost of domestic and foreign production.
Material and methods. 62 patients (62 eyes) with newly diagnosed primary open-angle glaucoma were randomized into 2 groups depending on the domestic and foreign drug latanoprost used for 1 month. Patients underwent a comprehensive examination, including visometry, biomicroscopy, Maklakov tonometry (10.0), computer perimetry, optical coherence tomography with examination of the retinal nerve fiber layer (RNFL) of the optic nerve head, and spectrofluorimetric examination of the limbal area.
Results. In the study groups, the achieved hypotensive effect after 1 month of instillation was 28-30% of the initial IOP level. Computed perimetry and retinal optical coherence tomography (RNFL) data indicate stabilization of glaucomatous opticopathy. The effect on the hypoxic state of the limbal zone after instillation of latanoprost was also recorded; no significant differences in clinical groups between foreign and domestic drugs were noted.
Conclusion. Spectrofluorimetric indicators of the limbal zone reflect the hypoxic effect of latanoprost, regardless of production.

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