THE ROLE OF SYSTEMIC RISK FACTORS IN THE PATHOGENESIS OF RETINAL VEIN OCCLUSION
Abstract
Retinal vein occlusion is one of the leading causes of vision loss in developed countries. The key role in the pathogenesis of retinal vein occlusion plays Wirchow’s triad that includes vessels wall injury, local blood circulation impairment and hypercoagulatin. The above-mentioned disorders develop under the influence of various risk factors and their combinations. Arterial hypertension, hyperlipidemia and diabetes mellitus are qualified as the independent risk factors for retinal vein occlusion. In the absence of the above-mentioned factors and in case of bilateral retinal vein occlusion or positive history for thromboembolic events thrombophilia and hyperhomocysteinemia should be ruled out. In certain cases retinal vein occlusion could develop secondary to systemic connective tissue disorders and infectious diseases (HIV, viral hepatitis, novel coronavirus disease) that are accompanied by retinal vasculitis.
About the Authors
A. B. GalimovaRussian Federation
V. U. Galimova
Russian Federation
References
1. Erfurth-Schmidt U., Garcia-Arumi J., Gerendas B.S., Midena E. [et al.] Guidelines for the management of retinal vein occlusion by the European Society of retina specialists (EURETINA). Ophthalmologica. 2019;242(3):123-162. (in Engl) https://doi.org/10.1159/000502041.
2. Astakhov Yu.S., Titarenko A.I., Tultseva S.N., Astakhov S.Yu. [et al.] Systemic risk factors for retinal vein occlusion in young and middle-aged patients. Arterial Hypertension. 2018;24(6):666-673 (In Russ). https://doi.org/10.18705/1607-419X-2018-24-6-666-673.
3. Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. Journal of Ophthalmology. 2014: article ID 724780. (in Engl) http://dx.doi.org/10.1155/2014/724780
4. Cheung N., Klein R., Wang J.J. [et al.] Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multiethnic study of atherosclerosis. Invest Ophthalmol Vis Sci. 2008;49:4297-4302. (in Engl)
5. Eye Disease Case-Control Study Group. Risk factors for central retinal vein occlusion. Arch Ophthalmol. 1996;114:545–554. (in Engl)
6. Di Capua M., Coppola A., Albisinni R., Tufano A. [et al.] Cardiovascular risk factors and outcome in patients with retinal vein occlusion. J Thromb Thrombolysis. 2010;30:16–22. (in Engl)
7. O'Mahoney P.R.A., Wong D.T., Ray J.G. Retinal vein occlusion and traditional risk factors for atherosclerosis. Arch Ophthalmol. 2008;126:692–699. (in Engl)
8. Kida T., Flammer J., Oku H., Konieczka K., [et al.] Vasoactivity of retinal veins: a potential involvement of endothelin-1 (ET-1) in the pathogenesis of retinal vein occlusion (RVO). Exp Eye Res. 2018;176:207-209. (in Engl) https://doi.org/10.1016/j.exer.2018.07.016.
9. Eye Disease Case-Control Study Group. Risk factors for branch retinal vein occlusion. Am J Ophthalmol. 1993;116:286–296. (in Engl)
10. Dodson P.M., Westwick J., Marks G., Kakkar V.V. [et al.] Beta-thromboglobulin and platelet factor 4 levels in retinal vein occlusion. Br J Ophthalmol. 1983;67(3):143-146. (in Engl) https://doi.org/10.1136/bjo.67.3.143.
11. Chang Y-Sh., Ho Ch-H., Chu Ch-Ch., Wang Jh-J., [et al.] Risk of retinal vein occlusion in patients with diabetes mellitus: A retrospective cohort study. Diabetes Res Clin Pract. 2021;171:108607. (in Engl) https://doi.org/10.1016/j.diabres.2020.108607.
12. Terasaki H., Ogura Y., Kitano S., [et al.] Management of diabetic macular edema in Japan: a review and expert opinion. Jpn J Ophthalmol. 2018;62(1):1-23. (in Engl)
13. Tultseva S.N. Trombophilia as a risk factor of central retinal vein thrombosis development in young people. Ophthalmology reports. 2008;1(1):46-51. (In Russ).
14. Astakhov Yu.S., Titarenko A.I., Tultseva S.N. [et al.] Systemic risk factors for retinal vein occlusion in young and middle-aged patients. Arterial Hypertension. 2018; 24(6): 666-673. (In Russ). https://doi.org/10.18705/1607-419X-2018-24-6-666-673.
15. Tultseva S.N. Rol' nasledstvennykh i priobretennykh faktorov trombofilii v patogeneze okklyuzii ven setchatki (The role of hereditary and acquired thrombophilia factors in the pathogenesis of retinal vein occlusion): avtoref. dis. … dok. med. nauk. – Spb. 2014:38 (In Russ).
16. Viera M.J., Campos A., do Camo A., Arruda H., [et al.] Trombophilic risk factors for retinal vein occlusion. Sci Rep. 2019;9:article ID 18972. (in Engl)
17. Kuhli-Hattenbach C., Miesbach W., Luchtenberg M., Kohnen T. [et al.] Elevated lipoprotein (a) levels are independent risk factor for retinal vein occlusion. Acta Ophthalmica. 2017;95(2):140-145. (in Engl) https://doi.org/10.1097/IAE.0b013e313181b9b3a0.
18. Sheth J.U., Narayanan R., Goyal J., Goyal V. Retinal vein occlusion in COVID-19. Indian Journal of Ophthalmology. 2020;68(10):2291-2293. (in Engl)
19. Zhang X-T., Zhong Y-F., Xue Y-Q., Li S-Q. [et al.] Clinical features of central retinal vein occlusion in young patients. Ophthalmol Ther. 2022;11:1409–1422. (in Engl) https://doi.org/10.1007/s40123-022-00534-7.
Review
For citations:
Galimova A.B., Galimova V.U. THE ROLE OF SYSTEMIC RISK FACTORS IN THE PATHOGENESIS OF RETINAL VEIN OCCLUSION. Bashkortostan Medical Journal. 2024;19(2):79-82. (In Russ.)