TEMPERATURE PATTERNS IN PATIENTS WITH COVID-PNEUMONIA AND COMORBID DISEASES
Abstract
Fever is the most obvious clinical symptom of COVID-19. Understanding the relationship between temperature patterns and the host response to infection can help stratify patients by severity of the disease.
The objective of the study was to determine the relationship between clinical and biochemical differences between temperature patterns and the survival profile of patients with COVID-pneumonia.
Material and methods. Prospective observational study was conducted in adult patients of the Republican Clinical Infectious Hospital and the Clinical Emergency Hospital (Ufa, the Republic of Bashkortostan) from March 2020 to November 2021 during the first 5 days of their hospitalization.
Results. 125 patients with COVID-19 were divided into three groups according to temperature patterns: normothermia group 1 (n=44), hyperthermia group 2 (n=62) and hypothermia group 3 (n=19). Hyperthermia patients had the highest levels of inflammatoфry biomarker - C-reactive protein (p<0.001). Hyperthermia increased the need for mandatory ventilation, vasopressors, and the risk of death (HR 1.44; 95% CI 1.04–1.98; p=0.027) in comparison with other temperature patterns.
Conclusions. Hyperthermia in patients with COVID-pneumonia is associated with increased levels of inflammatory biomarkers, the frequency of cardiovascular and respiratory failure.
About the Authors
E. Yu. Soloveychik
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
D. A. Valishin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. R. Shakirov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
G. L. Matuzov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
P. I. Mironov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
I. I. Lutfarakhmanov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Soloveychik E.Yu., Valishin D.A., Shakirov A.R., Matuzov G.L., Mironov P.I., Lutfarakhmanov I.I. TEMPERATURE PATTERNS IN PATIENTS WITH COVID-PNEUMONIA AND COMORBID DISEASES. Bashkortostan Medical Journal. 2023;18(3):18-25. (In Russ.)
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