FUNCTIONAL FEATURES OF THE PHAGOCYTIC LINK OF IMMUNITY IN HEMORRHAGIC FEVER WITH RENAL SYNDROME COMPLICATED BY ACUTE RENAL FAILURE

The objective is to study the functional reserves of oxygen-dependent metabolism of phagocytes in patients with hemorrhagic fever with renal syndrome (HFRS), depending on the severity of the process.

Material and methods. We examined 100 patients with the disease of varying severity, including 38 patients with severe forms of HFRS complicated by acute renal failure (ARF). The comparison group consisted of 46 healthy individuals. Luminol-dependent chemiluminescence (LDCL) recording was used to measure the number of phagocytes generating reactive oxygen species. The characteristics of the reserve capabilities of phagocytes were assessed by calculating the ratio of reserve to spontaneous luminescence. The absolute value of the reserve capabilities of phagocytes was determined by subtracting the maximum intensity of induced luminescence from the maximum intensity of spontaneous luminescence.

Results. The values of spontaneous oxygen-dependent metabolism in patients with severe HFRS with ARF were higher compared to patients with moderate and severe HFRS, and the rates of induced oxygen-dependent processes, on the contrary, were lower. These patterns determined a stronger drop in functional reserve in patients with HFRS complicated by ARF.

Conclusion. A decrease in the reserve of functional activity of phagocytes in HFRS patients with acute renal failure indicates a breakdown in the body's adaptive capabilities and a decrease in its protective immunoregulatory capabilities.

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