Experimental study of reproductive toxicity of burdock (Arctium lappa L.) leaf juice
Abstract
The purpose of the research is the study of burdock leaf juice effect on the reproductive function of laboratory rats in order to determine the feasibility of its use in pregnant women.
Material and methods. The intragastric administration of burdock leaf juice at doses of 1 and 10 ml/kg was given to Wistar rats throughout the period of pregnancy (days 1-19). At the end of the antenatal period, embryonic material was studied in half of the obtained females. The second group of females was kept for giving birth and nursing of infant rats to estimate their development in the postnatal period.
Results. As a result of the studies carried out, it was established that the burdock leaf juice did not exhibit embryotoxic and teratogenic properties and had no toxic effect on the postnatal development of the offspring when the doses exceeded the therapeutic ones by 10 and 100 times.
Conclusions. The results obtained suggest that a drug based on burdock leaves can be prescribed to pregnant women in the recommended therapeutic dose in further clinical trials.
About the Authors
A. N. Babenko
ФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений»
Russian Federation
Russian Federation
L. V. Krepkova
ФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений»
Russian Federation
Russian Federation
S. V. Lemyaseva
ФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений»
Russian Federation
Russian Federation
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Review
For citations:
Babenko A.N., Krepkova L.V., Lemyaseva S.V. Experimental study of reproductive toxicity of burdock (Arctium lappa L.) leaf juice. Bashkortostan Medical Journal. 2023;18(2):37-40. (In Russ.)
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