Pd-CONTAINING AZOLE COMPOUND: PROSPECTS FOR USE AS A WOUND HEALING AGENT IN DENTISTRY

Expanding the arsenal of drugs with antimicrobial and wound-healing properties is important in connection with the problem of resistance of pathogenic microorganisms to drugs. A heterocyclic palladium complex with S-Pd-S bonds with a bis-(sulfanylmethylazolyl)ethane ligand was synthesized, for which low toxicity and hepatoprotective properties were previously established. Biological tests of wound-healing effects have shown the promise of a palladium complex compound with regenerative properties for therapy in the maxillofacial area.
Purpose of the study. Development of a new wound healing agent, which in the future will be used in dental practice as a reparative drug with high efficacy, safety and a wide range of pharmacological effects: anti-inflammatory, antimicrobial, antioxidant and hepatoprotective properties.
Material and methods. The synthesis of the target compound is based on a multicomponent reaction of thiomethylation of acetylacetone with a mixture of formaldehyde – 1,2-ethanedithiol, heterocyclization with hydrazine, followed by a complexation reaction with PdCl2. Laboratory animals (non-linear mice and rats of both sexes, sexually mature), special equipment for performing surgery under sterile conditions, histological complex MICROM (Karl Zeiss, Germany), devices, reagents and equipment for preclinical experimental studies were used for biotesting.
Results. A highly effective wound healing agent has been identified, superior in reparative properties to actovegin and dexpanthenol, based on a model of experimental wounds in laboratory animals. The new azole compound Pd has a multicomponent pharmacological effect. Its hepatoprotective effect has been previously proven to be superior to the effect of ademetionin. The palladium compound does not have a negative effect on the indicators of general and biochemical blood tests. The results of the determination of acute toxicity by Litchfield-Wilcoxone and subacute toxicity by Lin K.K. indicate the safety of a promising wound-healing azole compound palladium.
Conclusion. A new highly effective palladium azole compound has been identified, which has shown wound healing properties and has a multicomponent effect.

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