HEPATOPROTECTIVE ACTIVITY OF BIOLOGICALLY ACTIVE SUBSTANCES OF MEDICINAL POLYPORE ON A MODEL OF HEPATOSIS IN RATS
Abstract
The use of hepatoprotective compounds accelerating the regeneration processes in hepatocytes is based on the restoration of cellular structures. In this regard, it is relevant to expand the range of effective medicines with hepatoprotective activity.
The objective of the study was to conduct biochemical research to study the degree of activity of the hepatoprotective effect of extracts from the fruit body of the polypore Fomitopsis officinalis L. in carbon tetrachloride intoxication.
Material and methods. A fraction of water-soluble compounds of the fruit body of the medicinal polypore Fomitopsis officinalis L. was obtained. The hepatoprotective effect was studied on a model of acute hepatosis. A 50% carbon tetrachloride oil solution was administered to white mongrel male rats per os. The administered dose was 0.15 ml per 100 g of body weight of rats (3 times in 24 hours). The effect of carbon tetrachloride was compared with Carsil hepatoprotector of plant origin.
Conclusion. Biologically active compounds of polypore are able to prevent and eliminate the consequences of toxic damage to the liver with carbon tetrachloride, which indicates the presence of hepatoprotective properties in the fruit body of polypore. The revealed influence on the indicators of acute toxic hepatosis ensures the prospects of using new cultivated strains of basidial fungi in the creation of hepatoprotective agents.
About the Authors
E. O. Sergeeva
Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава России
Russian Federation
Russian Federation
A. Y. Ayrapetova
Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава России
Russian Federation
Russian Federation
D. A. Konovalov
Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО ВолгГМУ Минздрава России
Russian Federation
Russian Federation
T. M. Dementeva
ФГБОУ ВО «Дальневосточный государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Sergeeva E.O., Ayrapetova A.Y., Konovalov D.A., Dementeva T.M. HEPATOPROTECTIVE ACTIVITY OF BIOLOGICALLY ACTIVE SUBSTANCES OF MEDICINAL POLYPORE ON A MODEL OF HEPATOSIS IN RATS. Bashkortostan Medical Journal. 2023;18(3):54-59. (In Russ.)
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