SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW O-THIETANYLTHIOURACIL ACETOHYDRAZIDE DERIVATIVES
Abstract
Objective. Synthesis of new diacylhydrazines based on thietane-containing 2-thiouracil derivatives as a promising direction for the creation of innovative biologically active substances with antimicrobial activity.
Material and methods. Diacylhydrazines based on thietane-containing 2-thiouracil derivatives were obtained by the interaction of 2-[6-methyl-4-(thietan-3-yloxy)pyrimidine-2-ilthio]acetohydrazide with carboxylic acids derivatives. The structure and individuality of the synthesized compounds are confirmed by data from nuclear magnetic resonance and infrared spectra, thin-layer chromatography, elemental analysis, and determination of the melting point. Antimicrobial activity was investigated by agar diffusion and tenfold broth dilution methods.
Results. The conditions of the reactions were selected to achieve the maximum yield of the target products, the structure of the synthesized compounds was established, and some structure-activity patterns were found for further modification of the radical in order to achieve the necessary pharmacological activity.
Conclusions. New O-thietanylthiouracil acetohydrazide derivatives have been synthesized and their antimicrobial activity has been investigated.
About the Authors
A. V. Shumadalova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. A. Meshcheryakova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
V. A. Kataev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Yu. I. Vinogradova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. K. Bulgakov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. A. Bulgakova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Shumadalova A.V., Meshcheryakova S.A., Kataev V.A., Vinogradova Yu.I., Bulgakov A.K., Bulgakova A.A. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW O-THIETANYLTHIOURACIL ACETOHYDRAZIDE DERIVATIVES. Bashkortostan Medical Journal. 2023;18(6):45-49. (In Russ.)
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