SUCCESSES IN THE TREATMENT OF ACUTE LEUKEMIA
Abstract
Acute leukemia accounts for approximately 2-3% of human malignant tumors; however, among hemoblastoses it occupies one of the first places in terms of frequency of occurrence. The incidence of acute leukemia averages 3-5 cases per 100000 of the population per year. In 75% of cases the pathology is diagnosed in adults, in 25% of cases in children. The average ratio of acute myeloid to lymphoid leukemia is 6:1. At the same time, persons over 40 years of age are statistically more frequently diagnosed with acute myeloid leukemia, while in children acute lymphoblastic leukemia is observed more often. For a long time, acute leukemia was considered incurable, but with timely treatment the recovery rate now ranges from 45% to 80%. This result has been achieved through the introduction of high-dose risk-based chemotherapy, hematopoietic stem cell transplantation and concomitant treatment, but unfortunately, there are still significant differences in the effectiveness of therapy. This literature review of current approaches to the treatment of acute leukemia presents predominantly Russian studies.
About the Authors
M. A. Stepchenko
ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
I. O. Malceva
ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. P. Samsonova
ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. R. Storubleva
ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
References
1. Afanas'eva A.A. Deistvie preparata blinatumomab pri lechenii ostrogo limfoblastnogo leikoza (The effect of blinatumomab in the treatment of acute lymphoblastic leukemia). FORCIPE. 2020;(3):792. (in Russ.)
2. Belousov K.A., Golenkov A.K., Kataeva E.V. The results of acute myeloid leukemia in everyday clinical practice. Almanac of clinical medicine. 2020;(41):66-71. (in Russ.)
3. Ganeeva E.R., Ketov N.A. Contemporary principles of diagnosis and treatment acute promyelocytic leukemia. European journal of natural history. 2020;(3):79-85. (in Russ.)
4. Borodulina A.A., Tenenchuk N.D. [et. al.] Genetika ostrogo mieloidnogo leikoza (Genetics of acute myeloid leukemia). Nauka i obrazovanie: aktual'nye voprosy, dostizheniya i innovatsii. 2022:158-160. (in Russ.)
5. Shatilova A.A [et. al.] Gilteritinib as a new option for the treatment of relapsed/refractory acute myeloid leukemias with FLT3 gene mutation: a literature review and three case reports. Clinical oncohematology. Basic research and clinical practice. 2023;16(1):69-79. (in Russ.)
6. Danilenko A.A., Shakhtarina S.V., Falaleeva N.A. COVID-19 in patients with oncohematological diseases. Clinical oncohematology. 2021;14 (2):220-224. (in Russ.)
7. Danilenko A.A., Shakhtarina S.V., Falaleeva N.A. Modern approaches to treatment of chronic lymphocytic leukemia. Siberian journal of oncology. 2020;19(6):106-118. (in Russ.)
8. Zukhovitskaya E.V., Fiyas A.T. High-dose cytarabine in acute myeloid leukemia treatment: a systematic review. Journal of Grodno State Medical University. 2019;(2):140-142. (in Russ.)
9. Iskrov I.A., Trubkina A.S., Lendina I. Monoclonal antibodies in the treatment of patients with acute lymphoblastic leukemia. Hematology. Transfusiology. Eastern Europe. 2022;8(2):122-129. (in Russ.)
10. Shuvaev V.A., Ushakova O.V. [et. al.] Use of blinatumomab in acute lymphoblastic leukemia in municipal healthcare: a case report. Clinical oncohematology. 2021;14(2):198–203. (in Russ.)
11. Meshcherina N.S. [et. al.[ Cardiovascular toxicity induced by chemotherapy and target drugs: meshanisms, diagnostic and preventive approaches. Man and his health. 2021;24(4):24-33. (in Russ.)
12. Aleksandrova T.N.[et. al.] Clinical case of successful treatment of COVID-19 infection manifested with B-cell acute lymphoblastic leukemia. Siberian journal of oncology. 2021;20(3):151-157. (in Russ.)
13. Korkina Y.S., Valiev T.T. Asparaginase drugg: a new view of the mechanism of action, side effects and experience in BFM protocolos. Russian journal of pediatric hematology and oncology. 2021;4(8):81-89. (in Russ.)
14. Ramazanova R.M., Kosanova A.K. [et. al.] Treatment of newly diagnosed acute promyelocytic leukemia in a pregnant woman. KAZNMU Bulletin. 2021;(3):8-12. (in Russ.)
15. Troitskaya V.V. [et. al.] Treatment of acute lymphoblastic leukemia during pregnancy according to the all-2009 protocol. Hematology and transfusiology. 2018;(4):209-230. (in Russ.)
16. Lomovskii A.I. [et al.] Melatonin Strengthens a Chemotherapeutic Effect of Cytarabin in HL-60 Cells. Biologicheskie membrany: Zhurnal membrannoi i kletochnoi biologii. 2020;37(2):103-109. (in Russ.)
17. Aleksandrova S.S. [et. al.] Mechanisms of development of side effects and drug resistance to asparaginase and ways to overcome them. Biomedical chemistry. 2022;68(2):104-116. (in Russ.)
18. Neganova M.E. [et. al.] Mechanisms of the cytotoxic action of novel cyclic hydroxamic acids. Biomedical chemistry. 2020;66(4):332-338. (in Russ.)
19. Ershov A.V. [et al.] The latest trends in improving CAR-T cell therapy: from leukemia to solid malignant tumors. Russian Journal of Pediatric Hematology and Oncology. 2021;2(8):85-95. (in Russ.)
20. Iskhakov E.D., Bakhramov S.M. [et. al.] Specific features of acute myeloid leukemia treatment in old age patients. Bulletin of hematology. 2019;(3):19-21. (in Russ.)
21. Parovichnikova E.N., Savchenko V.G. Russian multicenter clinical trials in acute leukemias. The therapeutic archive. 2019;91 (7):4-13. (in Russ.)
22. Kuzmina L.A., Konova Z.V., Parovichnikova E.N., Drokov M.Y., Vasilyeva V.A., Popova N.N., Savchenko V.G. Second allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies. Russian journal of hematology and transfusiology. 2019;64(1):35-48. (In Russ.) https://doi.org/10.35754/0234-5730-2019-64-1-35-48
23. Kuzmina L.A. [et. al.] Second allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies. Hematology and transfusiology. 2021;18(1):27-34. (in Russ.)
24. Gavrilina O.A., Kotova E.S., Parovichnikova E.N., Troitskaya V.V., Sokolov A.N., Baskhaeva G.A., Zarubina K.I., Fidarova Z.T., Kuzmina L.A., Dvirnyk V.N., Obukhova T.N., Savchenko V.G. Nelarabine treatment in adult patients with refractory/ relapsed t-cell acute lymphoblastic leukaemia/lymphoma: experience of a single centre. Russian journal of hematology and transfusiology. 2019;64(4):382-395. (In Russ.) https://doi.org/10.35754/0234-5730-2019-64-4-382-395
25. Rodionova M.D., Varlamova E.A., Bruter A.V. Vozmozhnosti ingibirovaniya proteinkinazy CDK 8 pri ostrom mieloidnom leikoze: sravnenie s tsitarabinom (Possibilities of inhibition of CDK 8 protein kinase in acute myeloid leukemia: comparison with cytarabine). VII Mezhdunarodnaya konferentsiya molodykh uchenykh: biofizikov, biotekhnologov, molekulyarnykh biologov i virusologov. 2020:534-535. (in Russ.)
26. Bazhenov A.V. [et. al.] Role of the intensive care in treatment of patients with acute myeloid leukemia. The therapeutic archive. 2019;91(7):14-24. (in Russ.)
27. Valiev TT, Semenova VV, Ikonnikova AY, Petrova AA, Belysheva TS, Nasedkina TV. Role of pharmacogenetic factors in the development of side effects of methotrexate in the treatment of malignant tumors: A review. Journal of Modern Oncology. 2021;23(4):622– 627. (in Russ.) doi: 10.26442/18151434.2021.4.201127
28. Klodzinskii A.A. [et. al.] Current state of diagnosis and treatment of acute myeloid leukemias in adult patients in the republic of Kazakhstan. Clinical oncohematology. Basic research and clinical practice. 2022;15(1):69-75. (in Russ.)
29. Solov'eva A.A. [et al.] Sochetannaya immunoterapiya blinatumomabom i targetnaya terapiya ingibitorami tirozinkinaz v lechenii retsidivov i refrakternykh form ostrykh limfoblastnykh leikozov(Combined immunotherapy with blinatumomab and targeted therapy with tyrosine kinase inhibitors in the treatment of relapses and refractory forms of acute lymphoblastic leukemia). Russian journal of hematology and transfusiology. 2020;(4):221. (in Russ.)
30. Davidyan Y.R. [et. al.] Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: results of the rall study group protocol. Clinical oncohematology. 2019;4(4):315-319. (in Russ.)
31. Tolstykh T.N. Novye terapevticheskie strategii lecheniya ostrogo mieloidnogo leikoza u vzroslykh (New therapeutic strategies for the treatment of acute myeloid leukemia in adults). Sbornik trudov konferentsii. 2023:13-14. (in Russ.)
32. Shamsutdinov V.A., Yuldasheva N.E. New methods of treatment of acute leukemia. Economy and society. 2022;93(2):1059-1064. (in Russ.)
33. Usikova E.V., Kaplanov K.D., Vorob'ev V.I., Lobanova T.I., Ul'yanova M.A., Kisilichina D.G., Kobzev Yu.N., Shikhbabaeva D.I., Vinogradova O.Yu., Ptushkin V.V. Efficacy of the combination of venetoclax and hypomethylating agents in the treatment of patients with primary, relapsed and/or refractory acute myeloid leukemia. Bulletin of the Medical Institute «Reaviz» (Rehabilitation, Doctor And Health). 2022;12(6):64-77. (In Russ.) https://doi.org/10.20340/vmi-rvz.2022.6.CLIN.5
34. Tretyak N. N., Goryainova N. V. [et. al.] Flag protocol-based cure rate of acute myeloid leukemia. Health and environmental issues. 2019;(4):85-87. (in Russ.)
35. Bondarenko S.N., Ayubova B.I. [et al.] Effektivnost' terapii gilteritinibom pri retsidiviruyushchem ili refrakternom ostrom mieloidnom leikoze FLT3 + u vzroslykh (The effectiveness of gilteritinib therapy in relapsing or refractory acute myeloid leukemia FLT3 + in adults). The Bulletin of Hematology. 2022;18(2):40-41. (in Russ.)
36. Budaeva I.G., Zaitsev D.V., Shatilova A.A., [et al.] Efficacy, safety and tolerability of gemtuzumab ozogamycin in combination with FLAG/FLAG-Ida or azacitidine in relapses and refractory course of acute myeloblastic leukemia. Clinical oncohematology. 2021;14(3):299–307. (in Russ.) doi: 10.21320/2500-2139-2021-14-3-299-307
Review
For citations:
Stepchenko M.A., Malceva I.O., Samsonova A.P., Storubleva S.R. SUCCESSES IN THE TREATMENT OF ACUTE LEUKEMIA. Bashkortostan Medical Journal. 2023;18(3):88-95. (In Russ.)
Views:
30
Email this article 
