Morphometric features of the spleen of white rats during correction of artificial immunosuppression by imunofan at the second week of gestation
Abstract
The aim of the study was to investigate the structural transformations of the spleen of pregnant rats during immunosuppression and subsequent immunostimulation at 2 weeks of gestation.
Material and methods. The study was carried out on 12 female white rats of the second week of gestation. To create an immunosuppressive state, rats were once injected with methotrexate at a dosage of 10 mg/m2 of body area, and correction was performed by using imunofan according to the scheme. The rats were excised at the end of the second trimester of pregnancy in compliance with all ethical standards. The mass, volume-linear and micromorphometric parameters of the organ were measured.
The results of the study. The experiment showed that the studied effect leads to statistically significant changes in the morphometric parameters of the rat spleen during pregnancy.
Conclusion. The results of the study indicate the active participation of this organ in the work of immune regulatory mechanisms in the body during gestation.
About the Authors
V. G. Lozychenko
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
A. A. Zakharov
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Lozychenko V.G., Zakharov A.A. Morphometric features of the spleen of white rats during correction of artificial immunosuppression by imunofan at the second week of gestation. Bashkortostan Medical Journal. 2024;19(4):37-41. (In Russ.)
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