PHENOTYPE FEATURES OF UMBILICAL CORD BLOOD MICROVESICLES IN NEWBORNS FROM MOTHERS WITH PREECLAMPSIA
I. G. Mustafin,
T. E. Kurmanbaev,
I. Yu. Kogan,
E. Yu. Yupatov,
R. M. Nabiullina,
Z. R. Mukhametzyanova,
M. D. Leonova Abstract
During pregnancy, the number and phenotype of various microvesicles varies significantly, especially in the presence of preeclampsia. It is known that placental microvesicles are able to penetrate the fetus, but the issue of the effect of the level of placental microvesicles on the fetus has not been sufficiently studied.
Aim. To study the phenotype of microvesicles in cord blood and the correlation of their level with the condition of newborns from females with preeclampsia.
Material and methods. A cross-sectional cohort study was conducted, including 105 newborns: 30 from mothers with severe preeclampsia and 35 with moderate, 40 from pregnant women without hypertensive syndrome. The level of circulating microvesicles was determined in cord blood using flow cytofluorimetry.
Results. Circulation of placental-type microvesicles and tissue factor microvesicles was detected in cord blood, the amount of which statistically significantly differed in the study groups depending on the severity of preeclampsia. A relationship was also established between the level of placental microvesicles and birth weight.
Conclusion. A relationship was established between the phenotype of cord blood microvesicles, the condition of newborns, their weight and the presence of preeclampsia in mothers.
About the Authors
I. G. Mustafin
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
T. E. Kurmanbaev
ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» Министерства обороны Российской Федерации
Russian Federation
Russian Federation
I. Yu. Kogan
ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта»
Russian Federation
Russian Federation
E. Yu. Yupatov
Казанская государственная медицинская академия – филиал ФГБОУ ДПО РМАНПО Минздрава России
Russian Federation
Russian Federation
R. M. Nabiullina
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Z. R. Mukhametzyanova
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
M. D. Leonova
СПб ГБУЗ «Родильный дом № 13»
Russian Federation
Russian Federation
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Review
For citations:
Mustafin I.G., Kurmanbaev T.E., Kogan I.Yu., Yupatov E.Yu., Nabiullina R.M., Mukhametzyanova Z.R., Leonova M.D. PHENOTYPE FEATURES OF UMBILICAL CORD BLOOD MICROVESICLES IN NEWBORNS FROM MOTHERS WITH PREECLAMPSIA. Bashkortostan Medical Journal. 2025;20(3):20-23. (In Russ.)
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