VALIDATION OF A COMPUTATIONAL METHOD FOR DETERMINING INSULIN RESISTANCE IN ADULT PATIENTS WITH TYPE 1 DIABETES MELLITUS
Abstract
Abstract. Insulin resistance increases the risk of developing chronic complications of type 1 diabetes.
Aim. To develop and validate a method to determine insulin resistance in adult patients with type 1 diabetes mellitus based on an assessment of insulin sensitivity.
Material and methods. 317 adult patients with type 1 diabetes mellitus and disease duration of more than a year were studied. Insulin sensitivity was calculated using the equations of Williams K.V, Epstein E.J., Thorn L.M., Dabelea D., Duca L.M., ZhengX. The cut-off points were determined using ROCanalysis.
Results. In the ROC analysis, insulin sensitivity determined by the Dabelea D. equation demonstrated the highest sensitivity and specificity values for the studied group of men (≤5.02 mg/kg/min, 100% and 93%, respectively) and females (≤5.64 mg/kg/min, 90.0% and 96.7%, respectively).
Conclusion. The Dabelea D. equation can be used in routine clinical practice to detect insulin resistance in adult patients with type 1 diabetes mellitus.
About the Authors
R. I. Malievskaya
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
O. A. Malievskiy
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. A. Ilyina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
D. Sh. Avzaletdinova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
T. V. Morugova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
I. Yu. Tarkhanova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Malievskaya R.I., Malievskiy O.A., Ilyina A.A., Avzaletdinova D.Sh., Morugova T.V., Tarkhanova I.Yu. VALIDATION OF A COMPUTATIONAL METHOD FOR DETERMINING INSULIN RESISTANCE IN ADULT PATIENTS WITH TYPE 1 DIABETES MELLITUS. Bashkortostan Medical Journal. 2025;20(3):24-28. (In Russ.)
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