CONCENTRATION OF BIOMARKERS OF ACUTE KIDNEY INJURY: Β2-MICROGLOBULIN, CYSTATIN C AND ALBUMIN IN URINE OF PATIENTS WITH THERMAL SKIN BURNS
Abstract
On the first day after a burn injury, it is difficult to diagnose acute kidney injury (AKI), which requires the search for new biomarkers that can indicate the onset of kidney damage. A modern trend in the diagnosis of acute kidney injury is the study of the level of new biomarkers that can identify the subclinical form of AKI and reflect the dynamics of the renal parenchyma at different stages of the course of burn disease. In this context, albumin, β2-microglobulin, and cystatin C, which are detectable in urine, are of the greatest interest.
Objective. To analyze dynamic changes in urine levels of albumin, β2-microglobulin, and cystatin C at different stages of burn disease in patients with thermal trauma.
Material and methods. This study involved 74 patients with severe skin burns. Protein concentration was studied by multiplex analysis on a flow cytofluorimeter.
Results. The new biomarkers demonstrated a multiple increase in concentration at all stages of burn disease.
Conclusions. The studied proteins can serve as a predictor of the development of acute kidney injury at all stages of burn disease.
About the Author
A. A. Konovalova
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Konovalova A.A. CONCENTRATION OF BIOMARKERS OF ACUTE KIDNEY INJURY: Β2-MICROGLOBULIN, CYSTATIN C AND ALBUMIN IN URINE OF PATIENTS WITH THERMAL SKIN BURNS. Bashkortostan Medical Journal. 2025;20(3):33-37. (In Russ.)
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