ASSESSMENT OF THE LARGE INTESTINE MICROBIOTA COMPOSITION IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE DISEASE (CMP)
Abstract
The aim of the work was to study the relationship between dysbiosis of the large intestine and diseases belonging to the group of CMP (true polycythemia, essential polycythemia, myelofibrosis, chronic monocytic leukemia).
Material and methods. The studied group included 110 patients of both sexes who applied to the BSMU Clinic (Ufa) during January 2024 to January 2025. Microflora of the large intestine was analyzed by real-time PCR using the COLONOFLOR-16 test system.
The results of the studies showed a significant change in the microbiota in 91.82% of the subjects: a decrease in the number of commensal microorganisms Lactobacillus spp., Bifidobacterium spp. and Faecalibacterium prausnitzii, as well as an increase in the titer of Enterobacter spp. and the coefficient of anaerobic imbalance, which possibly indicates a relationship with chronic inflammation and immunodeficiency in patients against the conducted therapy.
About the Authors
L. A. Mkhitarian
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
G. R. Zaripova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
D. G. Alexeev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. V. Minnibaeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. R. Khabibullina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Mkhitarian L.A., Zaripova G.R., Alexeev D.G., Minnibaeva A.V., Khabibullina S.R. ASSESSMENT OF THE LARGE INTESTINE MICROBIOTA COMPOSITION IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE DISEASE (CMP). Bashkortostan Medical Journal. 2025;20(3):38-41. (In Russ.)
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