POLYMORPHISMS OF VEGF, ENOS, MMP9, MMP12, IL-6, IL-28B, TP53, HIF1A AND ITGA2 GENES IN PATIENTS WITH BREAST AND OVARIAN CANCER IN THE REPUBLIC OF CRIMEA
Abstract
The aim of this study was to analyze the associations of significant polymorphisms of the VEGF, eNOS, MMP9, MMP12, IL-6, IL-28B, TP53, HiF1A and ITGA2 genes in patients with breast and ovarian cancer.
Material and methods. 148 individuals aged 36-75 years old were examined. Three groups were identified: with ovarian cancer (n=45), with breast cancer (n=52), control group (n=51) – healthy volunteers. Genotyping was performed using the polymerase chain reaction method for polymorphic loci of VEGF, eNOS, HIF1A, ITGA2, IL28B_1, MMP12, MMP9, IL6, TP53.
Results. Carrying the CC genotype of the rs1126643 polymorphism is associated with the risk of developing breast cancer (p<0.05) and ovarian cancer (p><0.01). CC polymorphism rs11549465 – breast cancer (p=0.47). GG polymorphism rs2010963 has a protective effect on ovarian cancer. Polymorphism rs1042522 affects the risk of ovarian cancer. Conclusion. Polymorphisms of the HIF1A rs11549465, ITGA2 rs1126643 genes are associated with the risk of developing breast cancer, and ITGA2 rs1126643, VEGF rs2010963 and TP53 rs1042522 with ovarian cancer. Key words: breast cancer, ovarian cancer, SNP, VEGF, eNOS, HIF1A, ITGA2, IL28B_1, MMP12, MMP9, IL-6, TP53.> < 0.05) and ovarian cancer (p < 0.01). CC polymorphism rs11549465 – breast cancer (p=0.47). GG polymorphism rs2010963 has a protective effect on ovarian cancer. Polymorphism rs1042522 affects the risk of ovarian cancer.
Conclusion. Polymorphisms of the HIF1A rs11549465, ITGA2 rs1126643 genes are associated with the risk of developing breast cancer, and ITGA2 rs1126643, VEGF rs2010963 and TP53 rs1042522 with ovarian cancer.
About the Authors
K. A. Aliev
Ордена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»
Russian Federation
Russian Federation
I. O. Golovkin
Ордена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»
Russian Federation
Russian Federation
E. Yu. Ziablitskaia
Ордена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»
Russian Federation
Russian Federation
L. D. Khakimova
Ордена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»
Russian Federation
Russian Federation
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Review
For citations:
Aliev K.A., Golovkin I.O., Ziablitskaia E.Yu., Khakimova L.D. POLYMORPHISMS OF VEGF, ENOS, MMP9, MMP12, IL-6, IL-28B, TP53, HIF1A AND ITGA2 GENES IN PATIENTS WITH BREAST AND OVARIAN CANCER IN THE REPUBLIC OF CRIMEA. Bashkortostan Medical Journal. 2025;20(4):5-9. (In Russ.)
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