CONTENT OF DIFFERENT SUBTYPES OF T-HELPER CELLS IN THE PRIMARY TUMOR SITE AND REGIONAL LYMPH NODES IN COLON CANCER
Abstract
Objective. To study the subpopulation composition of T-helpers in the primary tumor site and regional lymph nodes in patients with colorectal cancer.
Material and methods. The subpopulation composition of T-helpers was determined in 105 patients with colon cancer using flow cytometry. The control group consisted of 75 patients with non-neoplastic diseases of the colon.
Results. In patients with colorectal cancer, the relative content of type 1 T-helpers and type 2 T-follicular cells in the primary tumor site decreases by 1.4 times and 1.3 times respectively; the number of type 17 T-helpers increases. In the regional lymph nodes of patients with colorectal cancer, the relative content of type 2 T-helpers and type 1 T-follicular lymphocytes decreases by 1.6 times; the number of classical T-helpers type 17 increases by 1.8 times and T-follicular lymphocytes type 17 – by 2.9 times.
Conclusion. In patients with colorectal cancer, changes occur in the subpopulation composition of tumor-infiltrating T-helpers both in the primary focus of tumor growth and in the lymph nodes.
About the Authors
V. V. Kryukova
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
V. L. Tsepelev
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
P. P. Tereshkov
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Kryukova V.V., Tsepelev V.L., Tereshkov P.P. CONTENT OF DIFFERENT SUBTYPES OF T-HELPER CELLS IN THE PRIMARY TUMOR SITE AND REGIONAL LYMPH NODES IN COLON CANCER. Bashkortostan Medical Journal. 2025;20(4):9-13. (In Russ.)
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