INFLUENCE OF VARIOUS CONCENTRATIONS OF LIPOPOLYSACCHARIDE OF GRAM-NEGATIVE MICROORGANISMS ON THE PROCESS OF HEMOCOAGULATION DURING PREGNANCY

Lipopolysaccharide (endotoxin) is the main component of the outer membrane of gram-negative bacteria. Increased activity and amount of endotoxin in the systemic bloodstream is observed in various conditions, including preeclampsia, a pregnancy complication characterized by dysfunction of the hemostasis system. However, the issue of the effect of endotoxin on the hemostasis system remains unresolved.

Aim. To establish the effect of different concentrations of lipopolysaccharide of gram-negative microorganisms on the process of plasma coagulation during pregnancy.

Material and methods. An experimental study was conducted with 15 samples of platelet-free plasma from pregnant women in the third trimester of gestation. After a preliminary analysis of endotoxin activity using the LAL test, a series of experiments was conducted to assess the effect of different doses of endotoxin on the coagulation system.

Results. With an increase in the concentration of lipopolysaccharide of gram-negative microorganisms in the functioning of the hemostasis system, an acceleration of the initiation process and a change in the quality of the resulting fibrin fiber are observed. The degree of expression of the described changes linearly depends on the concentration of lipopolysaccharide.

Conclusion. Lipopolysaccharide of gram-negative microorganisms is capable to influence the process of hemocoagulation, which requires further research.

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