EFFECTIVENESS OF PHOTODYNAMIC THERAPY IN THE COMPREHENSIVE TREATMENT OF SPECIFIC ULCERATIVE LESIONS OF THE ORAL MUCOSA IN TUBERCULOSIS
Abstract
Objective. The purpose of the study is to evaluate the effectiveness of photodynamic therapy (PDT) as part of the comprehensive treatment of specific ulcerative lesions of the oral mucosa in tuberculosis.
Material and methods. A prospective cohort clinical study was conducted involving 60 patients (36 men, 24 women, mean age – 42.8±5.6 years old) randomized into two groups: the main group (n=30, PDT + chemotherapy) and the control group (n=30, chemotherapy only). Treatment efficacy was assessed using clinical, microbiological, and histological parameters. PDT was performed with methylene blue (1%) and a diode laser (660 nm, 100 mW, 2 minutes).
Results. The main group demonstrated significantly faster ulcer epithelialization (p=0.003), reduced inflammatory infiltration (p=0.007), and improved tissue regeneration (p=0.001). Bacterial load decreased more rapidly in the PDT group (p<0.001). Histological analysis revealed enhanced granulation tissue formation (p=0.012) and lower Mycobacterium tuberculosis expression (p=0.002).
Conclusion. PDT combined with chemotherapy significantly accelerates tissue healing, reduces inflammation and lowers bacterial load, making it a promising method for the treatment of tuberculosis-related ulcerative lesions of the oral mucosa.
About the Authors
V. Yu. Khanaliev
ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
M. N. Medzhidov
ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. T. Guseynova
ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
G. M-A. Budaychiev
ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Khanaliev V.Yu., Medzhidov M.N., Guseynova S.T., Budaychiev G.M. EFFECTIVENESS OF PHOTODYNAMIC THERAPY IN THE COMPREHENSIVE TREATMENT OF SPECIFIC ULCERATIVE LESIONS OF THE ORAL MUCOSA IN TUBERCULOSIS. Bashkortostan Medical Journal. 2025;20(4):36-40. (In Russ.)
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