DYNAMICS OF CHANGES IN MORPHOMETRIC PARAMETERS OF THE UMBILICAL CORD BASED ON THE RESULTS OF POST-NATAL STUDIES
Abstract
The aim of the study: to assess the nature and extent of morphofunctional changes in the structure of the umbilical cord based on the results of postnatal studies, to compare morphometric parameters of the umbilical cord in the antenatal and postnatal periods.
Material and methods. The object of the study was the umbilical cords (n = 150). Initially, antenatal morphometry of the umbilical cord was carried out using ultrasound scanning on a Samsung Accuvix XG 2019 device. At the next stage, the macromicropreparation method according to V.P. Vorobyov was used. Corrosion preparations were made from the proximal and median segments of the umbilical cord, on the basis of which three-dimensional computer models were subsequently built using a RangeVision Spectrum 3D scanner (Russia).
Results. The morphometric parameters obtained by ultrasound scanning statistically significantly exceed similar parameters recorded in the postnatal period, obtained using macro-micropreparation methods.
Conclusions. In the early postpartum period, the umbilical cord undergoes a number of morphometric changes. They are a direct result of the cessation of its key functions. The ranges of morphometric parameters of the umbilical cord presented by us demonstrate significant variability, characteristic of the boundaries of the normal anatomical structure.
About the Author
M. Yu. Klyavlina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
References
1. Felicia G. Vascular abnormalities of the umbilical cord. Medicus. 2022;(1(43)):6-13. (in Engl)
2. Nadeyev AP, Shkurupiy VA, Marinkin IO. Pechen' i platsenta v peri-i postnatal'nyy periody pri patologii: kliniko-eksperimental'noye issledovaniye (Liver and placenta in the peri- and postnatal periods in pathology: a clinical and experimental study). Novosibirsk: Nauka; 2014: 91-92. (in Russ)
3. Karpov AL, Karpov NO, Mostovoy AV, Kondakova NN. Morphometric parameters of the placenta and umbilical cord in term pregnancy. Akusherstvo i ginekologiya [Obstetrics and Gynecology]. 2015;99:123-128. (in Russ)
4. Popova IG, Protsenko YeV, Sitnikova OG, Nazarov SB, Kuz'menko GN, Kharlamova NV. Pathomorphological and biochemical features of the umbilical cord vessels endothelium in pregnancy complicated by preeclampsia. Problemy reproduktsii [Problems of Reproduction]. 2022;28(6):44–52. Available from: https://doi.org/10.17116/repro20222806144. (in Russ)
5. Davies JE, Walker JT, Keating A. Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells. Stem Cells Transl Med. 2017 Jul;6(7):1620-1630. (in Engl) doi: 10.1002/sctm.16-0492.
6. Bao Y, Huang S, Zhao Z. Comparison of Different Culture Conditions for Mesenchymal Stem Cells from Human Umbilical Cord Wharton’s Jelly for Stem Cell Therapy. Turk J Haematol. 2020 Feb 20;37(1):67-69. (in Engl) doi: 10.4274/tjh.galenos.2019.2019.0439.
7. Joerger-Messerli MS, Marx C, Oppliger B, et al. Mesenchymal stem cells from Wharton's jelly and amniotic fluid. Best Pract Res Clin Obstet Gynaecol 2016; 31:30–44. (in Engl)
8. Abbaszadeh H, Ghorbani F, Derakhshani M, Movassaghpour AA, Yousefi M, Talebi M, Shamsasenjan K. Regenerative potential of Wharton's jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy. J Cell Physiol. 2020 Dec;235(12):9230-9240. doi: 10.1002/jcp.29810. (in Engl)
9. Klyavlina MYu, Nigmatullin RT, Rybalko DYu, Maslennikov AV. Svidetel'stvo o gosudarstvennoy registratsii bazy dannykh № 2025620664 Rossiyskaya Federatsiya. Morfometricheskiye pokazateli pupoviny i yeye sosudov donoshennykh novorozhdennykh. (Morphometric parameters of the umbilical cord and its vessels in full-term newborns: Certificate of state registration of database No. 2025620664 Russian Federation). Zayavl. 27.01.2025: opubl. 10.02.2025. (in Russ)
10. Glukhovets IB. Organo- i gistometricheskiye pokazateli pupoviny v norme i pri patologii beremennosti (Organo- and histometric parameters of the umbilical cord in normal and pathological pregnancies). Arkhiv patologii. 2010;72(6):38-40.
11. Yarygina TA, Gasanova RM, Marzoyeva OV, Sypchenko YeV, Leonova YeI, Lyapin VM, Shchegolev AI, Gus AI. Pathological structure of the umbilical cord: what is beyond routine ultrasound examination in congenital heart disease in the fetus. Akusherstvo i ginekologiya [Obstetrics and Gynecology] 2024; 9: 12-21. Available from: https://dx.doi.org/10.18565/aig.2024.195. (in Russ)
12. Peter GJ Nikkels, Luiz Cesar Peres. Umbilical Cord Coiling: A Practical Guide. 2019. DOI:10.1007/978-3-319-97214-5_47. (in Engl)
13. Mitrofanova IV, Lutsay YeD. Variants of macro-microanatomy of the umbilical cord in pregnancy after in vitro fertilization. Orenburgskiy meditsinskiy vestnik [Orenburg Medical Bulletin]. 2023;11(3(43)):54-59. (in Russ)
14. Krasnopol'skogo VI, editor. Formirovaniye i patologiya platsenty (Formation and pathology of the placenta). Moscow: OAO Izdatel'stvo «Meditsina»; 2007. (in Russ)
15. Alsatou A, Petrovici V, Corolcova N. Clinico-morphological aspects and outcomes of the lean umbilical cord. Mold Med J. 2020;63(2):25-30. (in Engl) doi: 10.5281/zenodo.3865990.
Review
For citations:
Klyavlina M.Yu. DYNAMICS OF CHANGES IN MORPHOMETRIC PARAMETERS OF THE UMBILICAL CORD BASED ON THE RESULTS OF POST-NATAL STUDIES. Bashkortostan Medical Journal. 2025;20(4):40-45. (In Russ.)
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